Sorafenib N-oxide
Based on 1 Customer Validation
Sorafenib N-oxide is an active metabolite of sorafenib (HY-10201). Sorafenib N-oxide is a linear-mixed inhibitor of microsomal CYP3A4, with a Ki of 15 μM.
For research use only. We do not sell to patients.
- Purity: 99.7%
- CAS No.: 583840-03-3
- Formula: C21H16ClF3N4O4
- Molecular Weight:480.82
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CYP3A4 15 μM (Ki) |
Chemical Information
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CAS No. 583840-03-3
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Appearance Solid
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Molecular Weight 480.82
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Formula C21H16ClF3N4O4
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Color White to off-white
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SMILES
O=C(C1=CC(OC2=CC=C(NC(NC3=CC=C(Cl)C(C(F)(F)F)=C3)=O)C=C2)=CC=[N+]1[O-])NC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (266 KB)
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SDS (563 KB)
- English - EN (563 KB)
- Français - FR (563 KB)
- Deutsch - DE (563 KB)
- Norwegian - NO (563 KB)
- Español - ES (563 KB)
- Swedish - SV (563 KB)
- Italian - IT (563 KB)
- Korean - KR (563 KB)
- Portuguese - PT (563 KB)
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Handling Instructions (2659 KB)
References
[1]. Li L, et al. Quantitation of sorafenib and its active metabolite sorafenib N-oxide in human plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Nov 1;878(29):3033-8. [Content Brief]
[2]. Ghassabian S, et al. Sorafenib N-Oxide Is an Inhibitor of Human Hepatic CYP3A4. AAPS J. 2019 Jan 9;21(2):15. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sorafenib N-oxide Related Classifications
HY-133798 Related Classifications
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