58814-71-4
Chemical Structure
Chenodeoxycholic acid 3-glucuronide
- CAS No.: 58814-71-4
- Formula:C30H48O10
- Molecular Weight:568.70
IUPAC Name: 5-(hydroxymethyl-13C)furan-2,3,4,5-13C4-2-carbaldehyde-13C
InChIKey: GDNGOAUIUTXUES-BWGRGVIUSA-N
SMILES: C[C@@]12[C@]3([H])[C@]([C@@H](C[C@]1([H])C[C@@H](CC2)O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)C(O)=O)O)([H])[C@@]5([H])[C@](CC3)([C@@](CC5)([H])[C@H](C)CCC(O)=O)C
Biological Activity: Chenodeoxycholic acid 3-glucuronide is a derivative of chenodeoxycholic acid (HY-76847). Chenodeoxycholic acid 3-glucuronide activates FXR-dependent transcription, with an EC50 of 8 μM for hFXR. Chenodeoxycholic acid 3-glucuronide upregulates the expression of BSEP, OSTα, and OSTβ transporters. Chenodeoxycholic acid 3-glucuronide accumulates under cholestasis and biliary obstruction conditions, its levels decrease after biliary stent implantation, and it participates in the hepatic detoxification process of chenodeoxycholic acid. Chenodeoxycholic acid 3-glucuronide can be used in the study of cholestasis[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Chenodeoxycholic acid 3-glucuronide | 99.9% | Chenodeoxycholic acid 3-glucuronide is a derivative of chenodeoxycholic acid (HY-76847). Chenodeoxycholic acid 3-glucuronide activates FXR-dependent transcription, with an EC50 of 8 μM for hFXR. Chenodeoxycholic acid 3-glucuronide upregulates the expression of BSEP, OSTα, and OSTβ transporters. Chenodeoxycholic acid 3-glucuronide accumulates under cholestasis and biliary obstruction conditions, its levels decrease after biliary stent implantation, and it participates in the hepatic detoxification process of chenodeoxycholic acid. Chenodeoxycholic acid 3-glucuronide can be used in the study of cholestasis. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Mostarda S, et al. Synthesis, physicochemical properties, and biological activity of bile acids 3-glucuronides: Novel insights into bile acid signalling and detoxification. European journal of medicinal chemistry. 2018 Jan 20;144:349-358. [Content Brief]
- [2]. Trottier J, et al. Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver. Hepatology. 2006 Nov;44(5):1158-70. [Content Brief]
- [3]. Perreault M, et al. Urinary Elimination of Bile Acid Glucuronides under Severe Cholestatic Situations: Contribution of Hepatic and Renal Glucuronidation Reactions. Canadian journal of gastroenterology & hepatology. 2018;2018:8096314.
