58994-96-0
58994-96-0
Chemical Structure
Ranimustine
Synonym(s): MCNU
- CAS No.: 58994-96-0
- Formula:C10H18ClN3O7
- Molecular Weight:327.72
IUPAC Name: 1-(2-chloroethyl)-1-nitroso-3-(((2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methoxytetrahydro-2H-pyran-2-yl)methyl)urea
InChIKey: AHHFEZNOXOZZQA-ZEBDFXRSSA-N
SMILES: O[C@H]1[C@@H](OC)O[C@H](CNC(N(CCCl)N=O)=O)[C@@H](O)[C@@H]1O
Biological Activity: Ranimustine (MCNU) is a nitrosourea alkylating agent, can be used for research of chronic myelogenous leukemia and polycythemia vera[1][3][4].
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Ranimustine | Ranimustine (MCNU) is a nitrosourea alkylating agent, can be used for research of chronic myelogenous leukemia and polycythemia vera. | |||||||||||||||||||||
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References
- [1]. Kameoka Y, et al. Safety and efficacy of high-dose ranimustine (MCNU) containing regimen followed by autologous stem cell transplantation for diffuse large B-cell lymphoma. Int J Hematol. 2018 Nov;108(5):510-515. [Content Brief]
- [3]. Kitajima K, et al. [Chemotherapy of chronic myelogenous leukemia--VP(M) regimen initiated during its chronic phase, and evaluation of MCNU in the phase of blastic crisis]. Gan To Kagaku Ryoho. 1989 Nov;16(11):3573-9. Japanese. [Content Brief]
- [4]. Nagai M, et al. [Therapeutic effect of ranimustine (MCNU) on essential thrombocythemia and polycythemia vera]. Gan To Kagaku Ryoho. 1988 Dec;15(12):3267-70. Japanese. [Content Brief]
Keywords
