594839-88-0
Chemical Structure
Tafamidis
Synonym(s): Fx-1006A free acid
- CAS No.: 594839-88-0
- Formula:C14H7Cl2NO3
- Molecular Weight:308.12
IUPAC Name: 2-(3,5-dichlorophenyl)benzo[d]oxazole-6-carboxylic acid
InChIKey: TXEIIPDJKFWEEC-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C2N=C(C3=CC(Cl)=CC(Cl)=C3)OC2=C1)O
Biological Activity: Tafamidis (Fx-1006A (free acid)) is an orally active and selective transthyretin (TTR) stabilizer. Tafamidis binds to the thyroxine binding site with negative cooperativity, stabilizes the TTR tetramer, slows TTR tetramer dissociation and subunit exchange, and inhibits TTR fibril formation. Tafamidis can be used in research on nervous system-related diseases[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tafamidis | 99.93% | Tafamidis (Fx-1006A (free acid)) is an orally active and selective transthyretin (TTR) stabilizer. Tafamidis binds to the thyroxine binding site with negative cooperativity, stabilizes the TTR tetramer, slows TTR tetramer dissociation and subunit exchange, and inhibits TTR fibril formation. Tafamidis can be used in research on nervous system-related diseases. | ||||||||||||||||||||
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Tafamidis (Standard) | 99.24% | Tafamidis (Standard) (Fx-1006A (free acid) (Standard)) is the analytical standard of Tafamidis (HY-14852). This product is intended for research and analytical applications. Tafamidis (Fx-1006A (free acid)) is an orally active and selective transthyretin (TTR) stabilizer. Tafamidis binds to the thyroxine binding site with negative cooperativity, stabilizes the TTR tetramer, slows TTR tetramer dissociation and subunit exchange, and inhibits TTR fibril formation. Tafamidis can be used in research on nervous system-related diseases. | ||||||||||||||||||||
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Tafamidis-d3 | 99.39% | Tafamidis-d3 (Fx-1006A-d3 (free acid)) is the deuterated-labeled Tafamidis (HY-14852). Tafamidis (Fx-1006A (free acid)) is an orally active and selective transthyretin (TTR) stabilizer. Tafamidis binds to the thyroxine binding site with negative cooperativity, stabilizes the TTR tetramer, slows TTR tetramer dissociation and subunit exchange, and inhibits TTR fibril formation. Tafamidis can be used in research on nervous system-related diseases. | ||||||||||||||||||||
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-
Similarity Score 0.73
HY-14852ATafamidis meglumine -
Similarity Score 0.65
HY-13568Benoxaprofen -
Similarity Score 0.62
HY-153903RASP-IN-1 -
Similarity Score 0.61
HY-116873Flunoxaprofen -
Similarity Score 0.61
HY-W778179Benoxaprofen-13C,d3 -
Similarity Score 0.61
HY-171791WAY-166818 -
Similarity Score 0.60
![4-(Benzo[d]oxazol-2-yl)aniline Chemical Structure](//file.medchemexpress.com/product_pic/hy-w029411.gif)
HY-W0294114-(Benzo[d]oxazol-2-yl)aniline -
Similarity Score 0.59
HY-W193645SR10098 -
Similarity Score 0.59
HY-109027RCavosonstat (Standard) -
Explore the MedChemAI to find more analogs
![4-(Benzo[d]oxazol-2-yl)aniline Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w029411.gif)
References
- [1]. Lee K R, et al. Pharmacokinetics of tafamidis, a transthyretin amyloidosis drug, in rats. Xenobiotica, 2018, 48(8):831-838.
- [2]. Coelho T, et al. Mechanism of Action and Clinical Application of Tafamidis in Hereditary Transthyretin Amyloidosis. Neurology and therapy. 2016 Jun;5(1):1-25.
- [3]. Bulawa C E, et al. Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. PNAS, 2012, 109(24):9629-9634.
