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Cat. No.: HY-W193645

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SR10098

Name: SR10098
Brand: MedChemExpress
SKU: HY-W193645
Price: 40.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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SR10098 is a benzimidazole-based Nurr1 activator with an EC₅₀ of 24 nM against full-length Nurr1. SR10098 does not directly bind to the ligand-binding domain of Nurr1, regulates transcription via a Nurr1-independent pathway, and exhibits no significant cytotoxicity. SR10098 can be used in studies of Nurr1-related diseases, such as Alzheimer's disease and Parkinson's disease.

For research use only. We do not sell to patients.

Purity: ≥95.0%
CAS No.: 850705-30-5
Formula: C₁₄H₉FN₂O₂
Molecular Weight:256.24

Storage:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

SR10098 Chemical Structure

CAS No.: 850705-30-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

Nurr1/NR4A2

24 nM (EC₅₀)

All Nuclear Hormone Receptor 4A/NR4A Isoforms :

In Vitro

SR10098 (compound 1) weakly upregulates Nurr1-mediated transcription in HEK293T, PC12 and SK-N-BE (2)-C cells; it activates general transcription via a Nurr1-independent mechanism^[1].
SR10098 (400 μM) does not directly bind to the ligand-binding domain of Nurr1, as determined by protein NMR structural footprinting^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 850705-30-5
Appearance Solid
Molecular Weight 256.24
Formula C₁₄H₉FN₂O₂
Color White to off-white
SMILES

O=C(O)C1=CC=C2N=C(NC2=C1)C=3C=CC(F)=CC3
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Munoz-Tello P, et al. Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1. Journal of medicinal chemistry. 2020 Dec 24;63(24):15639-15654. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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SR10098

All Nuclear Hormone Receptor 4A/NR4A Isoforms