59875-58-0
Chemical Structure
Dehydro nicardipine
- CAS No.: 59875-58-0
- Formula:C26H27N3O6
- Molecular Weight:477.51
InChIKey: RAKLUKQABNIULI-UHFFFAOYSA-N
SMILES: O=C(C1=C(C2=CC=CC([N+]([O-])=O)=C2)C(C(OCCN(C)CC3=CC=CC=C3)=O)=C(C)N=C1C)OC
Biological Activity: Dehydro nicardipine is a dihydropyridine metabolite of Nicardipine (HY-12515) and belongs to the dihydropyridine class of compounds. Dehydro nicardipine can selectively inhibit the aggregation of Aβ monomers, specifically regulate the extension and binding of Aβ soluble aggregates, change the morphology of Aβ aggregates, and inhibit the growth of aggregate length. Dehydro nicardipine can be used in the study of Alzheimer's disease (AD)[1].
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Dehydro nicardipine | Dehydro nicardipine is a dihydropyridine metabolite of Nicardipine (HY-12515) and belongs to the dihydropyridine class of compounds. Dehydro nicardipine can selectively inhibit the aggregation of Aβ monomers, specifically regulate the extension and binding of Aβ soluble aggregates, change the morphology of Aβ aggregates, and inhibit the growth of aggregate length. Dehydro nicardipine can be used in the study of Alzheimer's disease (AD). | |||||||||||||||||||||
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Keywords
