60329-03-5
Chemical Structure
(E)-Guanabenz
Synonym(s): (E)-Wy-8678
- CAS. Nr.: 60329-03-5
- Formula:C8H8Cl2N4
- Molecular Weight:231.08
IUPAC Name: (E)-2-(2,6-dichlorobenzylidene)hydrazine-1-carboximidamide
InChIKey: WDZVGELJXXEGPV-YIXHJXPBSA-N
SMILES: ClC1=C(/C=N/NC(N)=N)C(Cl)=CC=C1
Biological Activity: (E)-Guanabenz ((E)-Wy-8678) is an orally active central α2-adrenoceptor agonist. (E)-Guanabenz has antihypertensive activity, acts via stimulating central α2-adrenoceptors, and reducing net sympathetic outflow into the periphery. (E)-Guanabenz also directly binds to and inhibits GADD34, and has neuroprotective activity. (E)-Guanabenz can be used for researching hypertension and Parkinson disease[1][2].
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(E)-Guanabenz | (E)-Guanabenz ((E)-Wy-8678) is an orally active central α2-adrenoceptor agonist. (E)-Guanabenz has antihypertensive activity, acts via stimulating central α2-adrenoceptors, and reducing net sympathetic outflow into the periphery. (E)-Guanabenz also directly binds to and inhibits GADD34, and has neuroprotective activity. (E)-Guanabenz can be used for researching hypertension and Parkinson disease. | |||||||||||||||||||||
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- [1]. Sun X, et al. Guanabenz promotes neuronal survival via enhancement of ATF4 and parkin expression in models of Parkinson disease. Exp Neurol. 2018 May;303:95-107. [Content Brief]
- [2]. Xie J, et al. LC-MS/MS determination of guanabenz E/Z isomers and its application to in vitro and in vivo DMPK profiling studies. J Pharm Biomed Anal. 2021 Oct 25;205:114331. [Content Brief]
Keywords
