6042-36-0
6042-36-0
Chemical Structure
WR-27653
Synonym(s): RC-12
- CAS No.: 6042-36-0
- Formula:C20H36BrN3O2
- Molecular Weight:430.42
InChIKey: HKEQSBHKLCETQW-UHFFFAOYSA-N
SMILES: BrC1=C(N(CCN(CC)CC)CCN(CC)CC)C=C(OC)C(OC)=C1
Biological Activity: WR-27653 (RC-12) is a derivative of Catechol with good activity against hypnozoites in the gold-standard Plasmodium cynomolgi-rhesus monkey (Macaca mulatta) model. WR-27653 has antimalarial activity[1][2].
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WR-27653 | WR-27653 (RC-12) is a derivative of Catechol with good activity against hypnozoites in the gold-standard Plasmodium cynomolgi-rhesus monkey (Macaca mulatta) model. WR-27653 has antimalarial activity. | |||||||||||||||||||||
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References
- [1]. Dong Y, et al. Metabolic, Pharmacokinetic, and Activity Profile of the Liver Stage Antimalarial (RC-12). ACS Omega. 2022 Mar 30;7(14):12401-12411. [Content Brief]
- [2]. Werbel LM, et al. Synthesis and physical properties of the antimalarial agent 4-(2-bromo-4,5-dimethoxyphenyl)-1,1,7,7-tetraethyldiethylenetriamine (RC-12) (WR-27,653). J Pharm Sci. 1967 Oct;56(10):1335-7. [Content Brief]
Keywords
