62-55-5
62-55-5
Chemical Structure
Thioacetamide
Synonym(s): Acetothioamide; TAA; Thiacetamide
- CAS No.: 62-55-5
- Formula:C2H5NS
- Molecular Weight:75.13
IUPAC Name: ethanethioamide
InChIKey: YUKQRDCYNOVPGJ-UHFFFAOYSA-N
SMILES: CC(N)=S
Biological Activity: Thioacetamide (TAA) is an indirect hepatotoxin and causes parenchymal cell necrosis. Thioacetamide requires metabolic activation by microsomal CYP2E1 to thioacetamide-S-oxide initially and then to thioacetamide-S-dioxide, which is a highly reactive metabolite, and its reactive metabolites covalently bind to proteins and lipids thereby causing oxidative stress and centrilobular necrosis. Thioacetamide can induce chronic liver fibrosis, encephalopathy and other events model[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Thioacetamide | 98.0% | Thioacetamide (TAA) is an indirect hepatotoxin and causes parenchymal cell necrosis. Thioacetamide requires metabolic activation by microsomal CYP2E1 to thioacetamide-S-oxide initially and then to thioacetamide-S-dioxide, which is a highly reactive metabolite, and its reactive metabolites covalently bind to proteins and lipids thereby causing oxidative stress and centrilobular necrosis. Thioacetamide can induce chronic liver fibrosis, encephalopathy and other events model. | ||||||||||||||||||||
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Thioacetamide (Standard) | ≥98% | Thioacetamide (Standard) is the analytical standard of Thioacetamide (HY-Y0698). This product is intended for research and analytical applications. Thioacetamide (TAA) is an indirect hepatotoxin and causes parenchymal cell necrosis. Thioacetamide requires metabolic activation by microsomal CYP2E1 to thioacetamide-S-oxide initially and then to thioacetamide-S-dioxide, which is a highly reactive metabolite, and its reactive metabolites covalently bind to proteins and lipids thereby causing oxidative stress and centrilobular necrosis. Thioacetamide can induce chronic liver fibrosis, encephalopathy and other events model. | ||||||||||||||||||||
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Dithiooxamide | 99.90% | Dithiooxamide (Rubeanic Acid) is a selective chelating agent and sulfur-containing analog of Oxamide. Dithiooxamide forms stable chelates with various metal ions (such as lead, iron, cadmium, manganese, and aluminum), which can be separated, enriched, and detected by adsorption on solid adsorbents or electrode surfaces. | ||||||||||||||||||||
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2-(Dimethylamino)ethanethioamide hydrochloride (Standard) | ≥98% | 2-(Dimethylamino)ethanethioamide hydrochloride (Standard) is the analytical standard of 2-(Dimethylamino)ethanethioamide hydrochloride. This product is intended for research and analytical applications. | ||||||||||||||||||||
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Acetamide-13C2,15N | Acetamide-13C2,15N is the 13C- and 15N-labeled Acetamide (HY-Y0946). Acetamide is used as an intermediate in the synthesis of methylamine, thioacetamide, and insecticides, and as a plasticizer in leather, cloth and coatings. Acetamide has carcinogenicity. Acetamide derivatives may has antioxidant activity and potential anti-inflammatory activity. Acetamide holds promise for research in the fields of anti-inflammatory and cancer studies. | |||||||||||||||||||||
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Thiosemicarbazide | 99.91% | Thiosemicarbazide is a vitamin B6 antagonist with anti-acne activity. Thiosemicarbazide is also a well-known source in the synthesis of heterocycles, and its derivatives have potential anticancer activity. Thiosemicarbazide (TSC: HL1) reacts with metal salts, urea (U), to prepare Co(II) and Cu(I) metal complexes. Thiosemicarbazide is also used in the fields of media communications and optical storage, and in the spectrophotometric detection of metals. | ||||||||||||||||||||
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2-Cyanothioacetamide | 2-Cyanothioacetamide is an antimicrobial agent with activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. 2-Cyanothioacetamide inhibits essential microbial enzymes and disrupts microbial cell membrane integrity.2-Cyanothioacetamide can be used for the research of bacterial infections and fungal infections. | |||||||||||||||||||||
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Acetamide | 99.95% | Acetamide is used as an intermediate in the synthesis of methylamine, thioacetamide, and insecticides, and as a plasticizer in leather, cloth and coatings. Acetamide has carcinogenicity. Acetamide derivatives may has antioxidant activity and potential anti-inflammatory activity. Acetamide holds promise for research in the fields of anti-inflammatory and cancer studies. | ||||||||||||||||||||
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Acetamide-15N | 99.0% | Acetamide-15N is the 15N-labeled Acetamide. Acetamide is used as an intermediate in the synthesis of methylamine, thioacetamide, and insecticides, and as a plasticizer in leather, cloth and coatings. Acetamide has carcinogenicity. | ||||||||||||||||||||
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Acetamide-13C2 | ||||||||||||||||||||||
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References
- [1]. Wallace MC, et, al. Standard operating procedures in experimental liver research: thioacetamide model in mice and rats. Lab Anim. 2015 Apr;49(1 Suppl):21-9. [Content Brief]
- [2]. Chen IS, et, al. Hepatoprotection of silymarin against thioacetamide-induced chronic liver fibrosis. J Sci Food Agric. 2012 May;92(7):1441-7. [Content Brief]
- [3]. Miranda AS, et, al. A thioacetamide-induced hepatic encephalopathy model in C57BL/6 mice: a behavioral and neurochemical study. Arq Neuropsiquiatr. 2010 Aug;68(4):597-602. [Content Brief]
- [4]. Yeom HJ, et, al. Expression analysis of early response-related genes in rat liver epithelial cells exposed to thioacetamide in vitro. J Vet Med Sci. 2009 Jun;71(6):719-27. [Content Brief]
