625095-60-5
625095-60-5
Chemical Structure
Pradefovir
- CAS No.: 625095-60-5
- Formula:C17H19ClN5O4P
- Molecular Weight:423.79
IUPAC Name: (2R,4S)-2-((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)-4-(3-chlorophenyl)-1,3,2-dioxaphosphinane 2-oxide
InChIKey: GWNHAOBXDGOXRR-HJFSHJIFSA-N
SMILES: NC1=C2N=CN(CCOC[P@]3(OCC[C@@H](C4=CC=CC(Cl)=C4)O3)=O)C2=NC=N1
Biological Activity: Pradefovir is a good substrate for liver CYP3A4. Pradefovir is converted to 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in human liver microsomes with a Km of 60 μM.
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Pradefovir | Pradefovir is a good substrate for liver CYP3A4. Pradefovir is converted to 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in human liver microsomes with a Km of 60 μM. | |||||||||||||||||||||
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Keywords
