63132-39-8
63132-39-8
Chemical Structure
Olpadronic acid
Synonym(s): Olpadronate; OLP
- CAS No.: 63132-39-8
- Formula:C5H15NO7P2
- Molecular Weight:263.12
IUPAC Name: (3-(dimethylamino)-1-hydroxypropane-1,1-diyl)bis(phosphonic acid)
InChIKey: UGEPSJNLORCRBO-UHFFFAOYSA-N
SMILES: O=P(O)(C(CCN(C)C)(P(O)(O)=O)O)O
Biological Activity: Olpadronic acid (Olpadronate) is an orally active amino-bisphosphonate and inhibits bone resorption. Olpadronic acid prevents bone destruction and tumor growth in the skeletal prostate cancer mouse model. Olpadronic acid can be used for research of osteoporosis, malignancies and rheumatoid arthritis[1][2][3].
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Olpadronic acid | 95.0% | Olpadronic acid (Olpadronate) is an orally active amino-bisphosphonate and inhibits bone resorption. Olpadronic acid prevents bone destruction and tumor growth in the skeletal prostate cancer mouse model. Olpadronic acid can be used for research of osteoporosis, malignancies and rheumatoid arthritis. | ||||||||||||||||||||
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Olpadronic acid (Standard) | ≥98% | Olpadronic acid (Standard) is the analytical standard of Olpadronic acid. This product is intended for research and analytical applications. Olpadronic acid is an orally active amino-bisphosphonate and inhibits bone resorption. Olpadronic acid prevents bone destruction and tumor growth in the skeletal prostate cancer mouse model. Olpadronic acid can be used for research of osteoporosis, malignancies and rheumatoid arthritis. | ||||||||||||||||||||
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References
- [1]. Roldán EJ, et al Olpadronate: a new amino-bisphosphonate for the treatment of medical osteopathies. Expert Opin Investig Drugs. 1998 Sep;7(9):1521-38. [Content Brief]
- [2]. Zeni SN, et al. Olpadronate prevents the bone loss induced by cyclosporine in the rat. Calcif Tissue Int. 2002 Jan;70(1):48-53. [Content Brief]
- [3]. Yang M, et al. The bisphosphonate olpadronate inhibits skeletal prostate cancer progression in a green fluorescent protein nude mouse model. Clin Cancer Res. 2006 Apr 15;12(8):2602-6. [Content Brief]
