64138-52-9
64138-52-9
Chemical Structure
4-Phenylbutyric acid-d5
Synonym(s): 4-PBA-d5;Benzenebutyric acid-d5
- CAS No.: 64138-52-9
- Formula:C10H7D5O2
- Molecular Weight:169.23
IUPAC Name: 4-(phenyl-d5)butanoic acid
InChIKey: OBKXEAXTFZPCHS-XFEWCBMOSA-N
SMILES: [2H]C1=C(CCCC(O)=O)C([2H])=C([2H])C([2H])=C1[2H]
Biological Activity: 4-Phenylbutyric acid-d5 is the deuterium labeled 4-Phenylbutyric acid[1]. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research[2][3][4].
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4-Phenylbutyric acid-d5 | 4-Phenylbutyric acid-d5 is the deuterium labeled 4-Phenylbutyric acid. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research. | |||||||||||||||||||||
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4-Phenylbutyric acid-d4 | 99.70% | 4-Phenylbutyric acid-d2 is the deuterium labeled 4-Phenylbutyric acid. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research. | ||||||||||||||||||||
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4-Phenylbutyric acid-d11 | 99.30% | 4-Phenylbutyric acid-d11 is the deuterium labeled 4-Phenylbutyric acid. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research. | ||||||||||||||||||||
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4-Phenylbutyric acid | 99.98% | 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Chang TH, et al. Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung. Clin Cancer Res. 2002 Apr;8(4):1206-12. [Content Brief]
- [3]. Frouco G, et, al. Sodium phenylbutyrate abrogates African swine fever virus replication by disrupting the virus-induced hypoacetylation status of histone H3K9/K14. Virus Res. 2017 Oct 15;242:24-29. [Content Brief]
- [4]. Park HJ, et al. 4-Phenylbutyric acid protects against lipopolysaccharide-induced bone loss by modulating autophagy in osteoclasts. Biochem Pharmacol. 2018 May;151:9-17. [Content Brief]
