6440-58-0
Chemical Structure
DMDM hydantoin
Synonym(s): Dimethyloldimethyl hydantoin
- CAS No.: 6440-58-0
- Formula:C7H12N2O4
- Molecular Weight:188.18
IUPAC Name: 1,3-bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione
InChIKey: WSDISUOETYTPRL-UHFFFAOYSA-N
SMILES: O=C1N(C(=O)C(N1CO)(C)C)CO
Biological Activity: DMDM hydantoin (Glydant) is an allergen and formaldehyde-releasing preservative. DMDM hydantoin releases formaldehyde under regulation by multiple factors and with enhanced release in alkaline environments. DMDM hydantoin induces allergic contact dermatitis via type-IV delayed hypersensitivity, either directly or through released formaldehyde. DMDM hydantoin is a broad-spectrum preservative that is effective against fungi, yeast, and gram-positive and gram-negative bacteria. DMDM hydantoin can be used in cosmetics industry production research (e.g., shampoos, hairsprays, and skincare products) and can be used for research on allergic contact dermatitis[1][2].
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DMDM hydantoin | DMDM hydantoin (Glydant) is an allergen and formaldehyde-releasing preservative. DMDM hydantoin releases formaldehyde under regulation by multiple factors and with enhanced release in alkaline environments. DMDM hydantoin induces allergic contact dermatitis via type-IV delayed hypersensitivity, either directly or through released formaldehyde. DMDM hydantoin is a broad-spectrum preservative that is effective against fungi, yeast, and gram-positive and gram-negative bacteria. DMDM hydantoin can be used in cosmetics industry production research (e.g., shampoos, hairsprays, and skincare products) and can be used for research on allergic contact dermatitis. | |||||||||||||||||||||
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- [1]. Nguyen HL, et al. Contact Dermatitis to Medications and Skin Products. Clin Rev Allergy Immunol. 2019;56(1):41-59. [Content Brief]
- [2]. de Groot A, et al. Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy. Part 2. Patch test relationship to formaldehyde contact allergy, experimental provocation tests, amount of formaldehyde released, and assessment of risk to consumers allergic to formaldehyde. Contact Dermatitis. 2010 Jan;62(1):18-31. [Content Brief]
Keywords
