65563-75-9
Chemical Structure
5α-Epoxyalantolactone
- CAS No.: 65563-75-9
- Formula:C15H20O3
- Molecular Weight:248.32
InChIKey: YIQKVCDNUFDAHB-HKKVUVRFSA-N
SMILES: C[C@]12[C@]3([C@H](CCC2)C)[C@@]([C@@]4([H])[C@@](OC(C4=C)=O)([H])C1)([H])O3
Biological Activity: 5α-Epoxyalantolactone is an orally active, blood-brain barrier-permeable ANXA2 inhibitor. 5α-Epoxyalantolactone binds to ANXA2, blocks the formation of ANXA2-S100A10 heterotetramers, inhibits the membrane trafficking of E-cadherin, and prevents metastasis of breast cancer cells as well as proliferation of breast cancer stem cells. 5α-Epoxyalantolactone improves cognitive and memory impairments by inhibiting the iNOS/COX-2/NF-κB pathway and reducing the activity of cerebral AChE. 5α-Epoxyalantolactone can be used in studies related to Alzheimer's disease and triple-negative breast cancer[1][2].
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5α-Epoxyalantolactone | 5α-Epoxyalantolactone is an orally active, blood-brain barrier-permeable ANXA2 inhibitor. 5α-Epoxyalantolactone binds to ANXA2, blocks the formation of ANXA2-S100A10 heterotetramers, inhibits the membrane trafficking of E-cadherin, and prevents metastasis of breast cancer cells as well as proliferation of breast cancer stem cells. 5α-Epoxyalantolactone improves cognitive and memory impairments by inhibiting the iNOS/COX-2/NF-κB pathway and reducing the activity of cerebral AChE. 5α-Epoxyalantolactone can be used in studies related to Alzheimer's disease and triple-negative breast cancer. | |||||||||||||||||||||
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- [1]. Ma R, et al. 5α-Epoxyalantolactone from Inula macrophylla attenuates cognitive deficits in scopolamine-induced Alzheimer's disease mice model. Natural products and bioprospecting. 2024 Jul 02;14(1):39.
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[2]. Wei M, et al. 5α-Epoxyalantolactone Inhibits Metastasis of Triple-Negative Breast Cancer Cells by Covalently Binding a Conserved Cysteine of Annexin A2. J Med Chem. 2021 Sep 9;64(17):12537-12547.
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Keywords
