658066-35-4
Chemical Structure
Fluopyram
- CAS. Nr.: 658066-35-4
- Formula:C16H11ClF6N2O
- Molecular Weight:396.71
IUPAC Name: N-(2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)ethyl)-2-(trifluoromethyl)benzamide
InChIKey: KVDJTXBXMWJJEF-UHFFFAOYSA-N
SMILES: FC(F)(F)C1=CC(Cl)=C(CCNC(C2=C(C(F)(F)F)C=CC=C2)=O)N=C1
Biological Activity: Fluopyram is an orally active succinate dehydrogenase inhibitor, antifungal and nematicide. Fluopyram inhibits succinate dehydrogenase activity, activates CAR/PXR nuclear receptors, and increases caspase-3, TNF-α and NF-κB. Fluopyram inhibits the growth of F. virguliforme, Botrytis cinerea and Alternaria solani with EC50 values of 3.35, 5.389 and 0.244 µg/mL, respectively. Fluopyram induces liver and thyroid tumor formation. Fluopyram is nephrotoxic and embryotoxic[1][2][3][4][5][6][7][8].
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Fluopyram | 99.76% | Fluopyram is an orally active succinate dehydrogenase inhibitor, antifungal and nematicide. Fluopyram inhibits succinate dehydrogenase activity, activates CAR/PXR nuclear receptors, and increases caspase-3, TNF-α and NF-κB. Fluopyram inhibits the growth of F. virguliforme, Botrytis cinerea and Alternaria solani with EC50 values of 3.35, 5.389 and 0.244 µg/mL, respectively. Fluopyram induces liver and thyroid tumor formation. Fluopyram is nephrotoxic and embryotoxic. | ||||||||||||||||||||
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Fluopyram (Standard) | 99.71% | Fluopyram (Standard) is the analytical standard of Fluopyram (HY-119459). This product is intended for research and analytical applications. Fluopyram is an orally active succinate dehydrogenase inhibitor, antifungal and nematicide. Fluopyram inhibits succinate dehydrogenase activity, activates CAR/PXR nuclear receptors, and increases caspase-3, TNF-α and NF-κB. Fluopyram inhibits the growth of F. virguliforme, Botrytis cinerea and Alternaria solani with EC50 values of 3.35, 5.389 and 0.244 µg/mL, respectively. Fluopyram induces liver and thyroid tumor formation. Fluopyram is nephrotoxic and embryotoxic. | ||||||||||||||||||||
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- [1]. Schleker ASS, et al. Mode of action of fluopyram in plant-parasitic nematodes. Sci Rep. 2022 Jul 13;12(1):11954. [Content Brief]
- [2]. Tinwell H, et al. Liver tumor formation in female rat induced by fluopyram is mediated by CAR/PXR nuclear receptor activation. Regul Toxicol Pharmacol. 2014 Dec;70(3):648-58. [Content Brief]
- [3]. Rouquié D, et al. Thyroid tumor formation in the male mouse induced by fluopyram is mediated by activation of hepatic CAR/PXR nuclear receptors. Regul Toxicol Pharmacol. 2014 Dec;70(3):673-80. [Content Brief]
- [4]. Zhang T, et al. Combined toxicity of trifloxystrobin and fluopyram to zebrafish embryos and the effect on bone development. Aquat Toxicol. 2024 Mar;268:106834. [Content Brief]
- [5]. Liu Y, et al. Oxidative stress, intestinal damage, and cell apoptosis: Toxicity induced by fluopyram in Caenorhabditis elegans. Chemosphere. 2022 Jan;286(Pt 3):131830. [Content Brief]
- [6]. Wang Y, et al. Different Size Formulations of Fluopyram: Preparation, Antifungal Activity, and Accumulation in the Fungal Pathogen Botrytis cinerea. Molecules. 2023 Aug 17;28(16):6099. [Content Brief]
- [7]. Özgöçmen M, et al. The Effect of Different Doses of Fluopyram on the Kidney Tissues of Mice. Erzincan University Journal of Science and Technology, 2021, 14(3): 970-978.
- [8]. Wang J, et al. Baseline Sensitivity of Fusarium virguliforme to Fluopyram Fungicide. Plant Dis. 2017 Apr;101(4):576-582. [Content Brief]
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