673443-80-6
673443-80-6
Chemical Structure
DCE_254
- CAS No.: 673443-80-6
- Formula:C21H17N9OS
- Molecular Weight:443.48
IUPAC Name: 2-((4-methylquinazolin-2-yl)amino)-6-(((1-phenyl-1H-tetrazol-5-yl)thio)methyl)pyrimidin-4(1H)-one
InChIKey: BPNPOVCTXJWVNP-UHFFFAOYSA-N
SMILES: O=C1N=C(NC(CSC2=NN=NN2C3=CC=CC=C3)=C1)NC4=NC(C)=C5C=CC=CC5=N4
Biological Activity: DCE_254 is an EZH2 inhibitor (IC50=11 μM) that also exhibits significant antiproliferative activity against lymphoma cell lines. DCE_254 inhibits the development of hypermethylation-related cancers by inhibiting the SAM-mediated methyl transfer process (IC50=10.3 μM)[1].
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DCE_254 | DCE_254 is an EZH2 inhibitor (IC50=11 μM) that also exhibits significant antiproliferative activity against lymphoma cell lines. DCE_254 inhibits the development of hypermethylation-related cancers by inhibiting the SAM-mediated methyl transfer process (IC50=10.3 μM). | |||||||||||||||||||||
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References
Keywords
