677306-35-3
677306-35-3
Chemical Structure
Facinicline
Synonym(s): RG3487 free base
- CAS No.: 677306-35-3
- Formula:C15H18N4O
- Molecular Weight:270.33
IUPAC Name: (S)-N-(quinuclidin-3-yl)-1H-indazole-3-carboxamide
InChIKey: TXCYUSKWBHUVEP-CYBMUJFWSA-N
SMILES: O=C(C1=NNC2=C1C=CC=C2)N[C@@H]3CN4CCC3CC4
Biological Activity: Facinicline (RG3487) is an orally active nicotinic α7 receptor partial agonist, with a Ki of 6 nM for α7 human nAChR. Facinicline improves cognition and sensorimotor gating in rodents. Facinicline hydrochloride shows high affinity (antagonist) to 5-HT3Rs with a Ki value of 1.2 nM[1].
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Facinicline | Facinicline (RG3487) is an orally active nicotinic α7 receptor partial agonist, with a Ki of 6 nM for α7 human nAChR. Facinicline improves cognition and sensorimotor gating in rodents. Facinicline hydrochloride shows high affinity (antagonist) to 5-HT3Rs with a Ki value of 1.2 nM. | |||||||||||||||||||||
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References
Keywords
