6850-28-8
Chemical Structure
THAM acetate
Synonym(s): Tris acetate; Tris(hydroxymethyl)aminomethane acetate
- CAS No.: 6850-28-8
- Formula:C6H15NO5
- Molecular Weight:181.19
IUPAC Name: 2-amino-2-(hydroxymethyl)propane-1,3-diol acetate
InChIKey: PIEPQKCYPFFYMG-UHFFFAOYSA-N
SMILES: OCC(CO)(N)CO.OC(C)=O
Biological Activity: THAM acetate is a low-toxicity amino alcohol buffer, a CO2-consuming proton acceptor that buffers carbon dioxide and acid both in vitro and in vivo. THAM acetate binds protons to form bicarbonate, reduces PaCO2, and induces intracellular alkalization, thereby ameliorating hypercapnia-induced elevation of pulmonary blood vessels and pulmonary arterial pressure. THAM acetate may cause PaCO2 rebound, hypoglycemia, and respiratory depression. THAM acetate removes amniotic epithelium and preserves the basement membrane, but depletes extracellular matrix and reduces the adhesion rate of limbal epithelial cells. THAM acetate can act as a CO2 carrier to enhance the productivity and carbon utilization rate of Scenedesmus obliquus. THAM acetate is a key component of buffer solutions used in various biological, cell culture, biochemical, and molecular biology applications[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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THAM acetate | 97.0% | THAM acetate is a low-toxicity amino alcohol buffer, a CO2-consuming proton acceptor that buffers carbon dioxide and acid both in vitro and in vivo. THAM acetate binds protons to form bicarbonate, reduces PaCO2, and induces intracellular alkalization, thereby ameliorating hypercapnia-induced elevation of pulmonary blood vessels and pulmonary arterial pressure. THAM acetate may cause PaCO2 rebound, hypoglycemia, and respiratory depression. THAM acetate removes amniotic epithelium and preserves the basement membrane, but depletes extracellular matrix and reduces the adhesion rate of limbal epithelial cells. THAM acetate can act as a CO2 carrier to enhance the productivity and carbon utilization rate of Scenedesmus obliquus. THAM acetate is a key component of buffer solutions used in various biological, cell culture, biochemical, and molecular biology applications. | ||||||||||||||||||||
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Similarity Score 0.83
HY-D0227THAM -
Similarity Score 0.82
HY-D0227ATHAM hydrochloride -
Similarity Score 0.81
HY-D0860Tricine -
Similarity Score 0.79
HY-W165722Tris(hydroxymethyl)methylammonium dihydrogen phosphate -
Similarity Score 0.79
HY-W795955Tris phosphate dibasic -
Similarity Score 0.79
HY-W558568Tris hemisulfate,98% -
Similarity Score 0.74
HY-W017411Tris(hydroxymethyl)nitromethane -
Similarity Score 0.74
HY-W008467(S)-2-amino-3-hydroxy-2-methylpropanoic acid -
Similarity Score 0.74
HY-W0128732-Amino-3-hydroxy-2-methylpropanoic acid -
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References
- [1]. Nahas GG, et al. Guidelines for the treatment of acidaemia with THAM. Drugs. 1998;55(2):191-224. [Content Brief]
- [2]. Höstman S, et al. THAM reduces CO2-associated increase in pulmonary vascular resistance - an experimental study in lung-injured piglets. Crit Care. 2015;19(1):331. Published 2015 Sep 17. [Content Brief]
