69113-01-5
Chemical Structure
N-Nitroso-tris-chloroethylurea
- CAS No.: 69113-01-5
- Formula:C7H12Cl3N3O2
- Molecular Weight:276.55
InChIKey: KIRNCVMRJCUYPS-UHFFFAOYSA-N
SMILES: O=NN(CCCl)C(N(CCCl)CCCl)=O
Biological Activity: N-Nitroso-tris-chloroethylurea is a DNA-alkylating chemical carcinogen and a trichloronitrosamine derivative. N‑Nitroso‑tris‑chloroethylurea induces a series of pathological changes such as bronchial hyperplasia, metaplasia, and atypical hyperplasia, ultimately driving the formation of lung squamous cell carcinoma. N-nitroso-tris-chloroethylurea can be used to establish chemically induced lung squamous cell carcinoma models. N-Nitroso-tris-chloroethylurea can be used in research related to lung squamous cell carcinoma[1][2][3].
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N-Nitroso-tris-chloroethylurea | N-Nitroso-tris-chloroethylurea is a DNA-alkylating chemical carcinogen and a trichloronitrosamine derivative. N‑Nitroso‑tris‑chloroethylurea induces a series of pathological changes such as bronchial hyperplasia, metaplasia, and atypical hyperplasia, ultimately driving the formation of lung squamous cell carcinoma. N-nitroso-tris-chloroethylurea can be used to establish chemically induced lung squamous cell carcinoma models. N-Nitroso-tris-chloroethylurea can be used in research related to lung squamous cell carcinoma. | |||||||||||||||||||||
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References
- [1]. Zhang Q, et al. Effect of weekly or daily dosing regimen of Gefitinib in mouse models of lung cancer. Oncotarget. 2017 Sep 22;8(42):72447-72456.
- [2]. Gómez-López S, et al. Mapping lung squamous cell carcinoma pathogenesis through in vitro and in vivo models. Communications biology. 2021 Aug 05;4(1):937. [Content Brief]
- [3]. Zhang Q, et al. Aerosolized miR-138-5p and miR-200c targets PD-L1 for lung cancer prevention. Front. Immunol., 2023, 14: 1166951.
