692737-80-7
692737-80-7
Chemical Structure
Dovitinib lactate
Synonym(s): CHIR-258 lactate; TKI-258 lactate
- CAS No.: 692737-80-7
- Formula:C24H27FN6O4
- Molecular Weight:482.51
IUPAC Name: 4-amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one 2-hydroxypropanoate
InChIKey: ZRHDKBOBHHFLBW-UHFFFAOYSA-N
SMILES: O=C(N1)C(C(NC2=C3)=NC2=CC=C3N4CCN(C)CC4)=C(N)C5=C1C=CC=C5F.O=C(O)C(C)O
Biological Activity: Dovitinib lactate (TKI258 lactate) is a multi-targeted tyrosine kinase inhibitor with IC50s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/3, VEGFR1/2/3 and PDGFRα/β, respectively[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Dovitinib lactate | 99.75% | Dovitinib lactate (TKI258 lactate) is a multi-targeted tyrosine kinase inhibitor with IC50s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/3, VEGFR1/2/3 and PDGFRα/β, respectively. | ||||||||||||||||||||
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Dovitinib lactate (Standard) | ≥98% | Dovitinib (lactate) (Standard) is the analytical standard of Dovitinib (lactate). This product is intended for research and analytical applications. Dovitinib lactate (TKI258 lactate) is a multi-targeted tyrosine kinase inhibitor with IC50s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/3, VEGFR1/2/3 and PDGFRα/β, respectively. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.99
HY-B0062Dovitinib lactate hydrate -
Similarity Score 0.92
HY-13892Dovitinib dilactic acid -
Similarity Score 0.91
HY-50905RDovitinib (Standard) -
Similarity Score 0.66
HY-132150AHPK1-IN-2 dihydrochloride -
Similarity Score 0.64
HY-50905SDovitinib-d8 -
Similarity Score 0.56
HY-15558AHoechst 33258 trihydrochloride -
Similarity Score 0.56
HY-15624Hoechst 33258 analog 2 -
Similarity Score 0.56
HY-15622meta-iodoHoechst 33258 -
Similarity Score 0.56
HY-15623Hoechst 33258 analog -
Explore the MedChemAI to find more analogs
