692744-81-3
Chemical Structure
IBT21
- CAS 番号: 692744-81-3
- Formula:C16H12N2O2S2
- Molecular Weight:328.41
IUPAC Name: 7-(methylsulfonyl)-2-phenylbenzo[d]imidazo[2,1-b]thiazole
InChIKey: AYLAIOGYDIIDEJ-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C2C(SC3=NC(C4=CC=CC=C4)=CN32)=C1)(C)=O
Biological Activity: IBT21 is an endoplasmic reticulum stress inhibitor that binds to unfolded or misfolded proteins and prevents their aggregation. IBT21 inhibits UPR activation of the ATF6, IRE1 and PERK branches under ER stress, with IC50 values of 0.24 μM, 0.33 μM, and 0.46 μM, respectively. IBT21 protects cells from ER stress-induced death and mutant prion protein (protein toxin)-induced growth inhibition. IBT21 exhibits chemical chaperone activity distinct from UPR modulators, does not affect protein translation, moderately reduces DTT (HY-15917)-induced ER stress, and fails to inhibit the heat shock response. IBT21 is useful for research related to prion diseases[1].
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IBT21 | IBT21 is an endoplasmic reticulum stress inhibitor that binds to unfolded or misfolded proteins and prevents their aggregation. IBT21 inhibits UPR activation of the ATF6, IRE1 and PERK branches under ER stress, with IC50 values of 0.24 μM, 0.33 μM, and 0.46 μM, respectively. IBT21 protects cells from ER stress-induced death and mutant prion protein (protein toxin)-induced growth inhibition. IBT21 exhibits chemical chaperone activity distinct from UPR modulators, does not affect protein translation, moderately reduces DTT (HY-15917)-induced ER stress, and fails to inhibit the heat shock response. IBT21 is useful for research related to prion diseases. | |||||||||||||||||||||
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