6949-03-7
Chemical Structure
NCI-65828 sodium
Synonym(s): N-65828 sodium
- CAS No.: 6949-03-7
- Formula:C22H16N3NaO4S
- Molecular Weight:441.43
IUPAC Name: (E)-8-amino-5-((4'-hydroxy-[1,1'-biphenyl]-4-yl)diazenyl)naphthalene-2-sulfonic acid, sodium salt
InChIKey: IKGWSKUMUVVHGJ-QREUMGABSA-M
SMILES: O=S(C1=CC2=C(C(/N=N/C3=CC=C(C4=CC=C(O)C=C4)C=C3)=CC=C2N)C=C1)(O[Na])=O
Biological Activity: NCI-65828 (N-65828) sodium is a cell-permeable small molecule inhibitor. NCI-65828 inhibits the ribonuclease activity of human angiogenin and zebrafish Rnasel-1/3, as well as the activity of Mycobacterium tuberculosis AccD5 and its holoenzyme complex. NCI-65828 induces neuronal developmental defects, impairs vascular development, inhibits neurite outgrowth, and reduces protein synthesis in stem cells and neural progenitor cells, but shows no significant growth inhibitory effect on various human tumor cell lines. NCI-65828 is primarily used to study the role of angiogenin-like ribonucleases in neural and vascular development, to establish effect models of ALS-related angiogenin mutants, and in research related to amyotrophic lateral sclerosis, frontotemporal dementia, and tuberculosis[1][2][3][4].
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NCI-65828 sodium | NCI-65828 (N-65828) sodium is a cell-permeable small molecule inhibitor. NCI-65828 inhibits the ribonuclease activity of human angiogenin and zebrafish Rnasel-1/3, as well as the activity of Mycobacterium tuberculosis AccD5 and its holoenzyme complex. NCI-65828 induces neuronal developmental defects, impairs vascular development, inhibits neurite outgrowth, and reduces protein synthesis in stem cells and neural progenitor cells, but shows no significant growth inhibitory effect on various human tumor cell lines. NCI-65828 is primarily used to study the role of angiogenin-like ribonucleases in neural and vascular development, to establish effect models of ALS-related angiogenin mutants, and in research related to amyotrophic lateral sclerosis, frontotemporal dementia, and tuberculosis. | |||||||||||||||||||||
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References
- [1]. Ferguson R, et al. The catalytic activity and secretion of zebrafish RNases are essential for their in vivo function in motor neurons and vasculature. Scientific reports. 2019 Feb 01;9(1):1107.
- [2]. Lin TW, et al. Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 2006 Feb 28;103(9):3072-7.
- [3]. Padhi AK, et al. Mechanisms of loss of functions of human angiogenin variants implicated in amyotrophic lateral sclerosis. PloS one. 2012;7(2):e32479.
- [4]. Ferguson R, et al. Neural stem cell homeostasis is affected in cortical organoids carrying a mutation in Angiogenin[J]. The Journal of Pathology, 2024, 262(4): 410-426.
