69935-18-8
Chemical Structure
Minoxidil hydrochloride
Synonym(s): U10858 hydrochloride
- CAS No.: 69935-18-8
- Formula:C9H16ClN5O
- Molecular Weight:245.71
InChIKey: ZVKNZHNATYIRMV-UHFFFAOYSA-N
SMILES: N=C1N=C(N2CCCCC2)C=C(N1O)N.Cl
Biological Activity: Minoxidil hydrochloride (U10858 hydrochloride) is an orally active ATP-sensitive potassium channel opener and vasodilator. Minoxidil hydrochloride activates Wnt/β-catenin signaling pathway, increases ERK and Akt phosphorylation, upregulates Bcl-2 and downregulates Bax, thereby promoting dermal papilla cell proliferation and hair follicle elongation. Minoxidil hydrochloride downregulates IL-1α, inhibits T lymphocyte activity, reduces 5α-reductase expression, and attenuates the transcriptional activity of androgen receptor. Minoxidil hydrochloride is converted by hair follicle sulfotransferase to Minoxidil sulfate, shortening telogen and prolonging anagen. Minoxidil hydrochloride can be used in research related to hair loss[1][2][3][4][5][6][7].
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Minoxidil hydrochloride | Minoxidil hydrochloride (U10858 hydrochloride) is an orally active ATP-sensitive potassium channel opener and vasodilator. Minoxidil hydrochloride activates Wnt/β-catenin signaling pathway, increases ERK and Akt phosphorylation, upregulates Bcl-2 and downregulates Bax, thereby promoting dermal papilla cell proliferation and hair follicle elongation. Minoxidil hydrochloride downregulates IL-1α, inhibits T lymphocyte activity, reduces 5α-reductase expression, and attenuates the transcriptional activity of androgen receptor. Minoxidil hydrochloride is converted by hair follicle sulfotransferase to Minoxidil sulfate, shortening telogen and prolonging anagen. Minoxidil hydrochloride can be used in research related to hair loss. | |||||||||||||||||||||
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References
- [1]. Yu NY, et al. Radiofrequency Microporation Enhances Topical Minoxidil Delivery and Hair Regeneration in Androgenetic Alopecia. Pharmaceutics. 2026 Aug 28;18(9):1081.
- [2]. Han JH, et al. Effect of minoxidil on proliferation and apoptosis in dermal papilla cells of human hair follicle. Journal of dermatological science. 2004 Apr;34(2):91-8.
- [3]. Kubilus J, et al. Effect of minoxidil on pre- and postconfluent keratinocytes. Journal of the American Academy of Dermatology. 1987 Mar;16(3 Pt 2):648-52.
- [4]. Cohen RL, et al. Direct effects of minoxidil on epidermal cells in culture. Journal of investigative dermatology. 1984 Jan 1;82(1).
- [5]. Choi N, et al. Minoxidil Promotes Hair Growth through Stimulation of Growth Factor Release from Adipose-Derived Stem Cells. International journal of molecular sciences. 2018 Feb 28;19(3):691.
- [6]. Doubkova M, et al. Harnessing the biomimetic effect of macromolecular crowding in the cell-derived model of clubfoot fibrosis. Biomacromolecules. 2024 Oct 14;25(10):6485-502.
- [7]. Handa JT, et al. Minoxidil inhibits ocular cell proliferation and lysyl hydroxylase activity. Investigative ophthalmology & visual science. 1993 Mar;34(3):567-75.
