69935-18-8
69935-18-8
Chemical Structure
Minoxidil hydrochloride
Synonym(s): U10858 hydrochloride
- No. CAS: 69935-18-8
- Formula:C9H16ClN5O
- Molecular Weight:245.71
InChIKey: ZVKNZHNATYIRMV-UHFFFAOYSA-N
SMILES: N=C1N=C(N2CCCCC2)C=C(N1O)N.Cl
Biological Activity: Minoxidil (U10858) hydrochloride is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil hydrochloride is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM[1][2][3].
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Minoxidil hydrochloride | Minoxidil (U10858) hydrochloride is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil hydrochloride is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM. | |||||||||||||||||||||
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References
- [1]. Hadjipavlou-Litina D, et al. Synthesis and evaluation of the antioxidative potential of minoxidil-polyamine conjugates. Biochimie. 2013 Jul;95(7):1437-49. [Content Brief]
- [2]. Davies GC, et al. Novel and established potassium channel openers stimulate hair growth in vitro: implications for their modes of action in hair follicles. J Invest Dermatol. 2005 Apr;124(4):686-94. [Content Brief]
- [3]. Cohen RL, et al. Direct effects of minoxidil on epidermal cells in culture. J Invest Dermatol. 1984 Jan;82(1):90-3. [Content Brief]
