70958-86-0
Chemical Structure
Amosulalol hydrochloride
Synonym(s): YM 09538 hydrochloride
- CAS No.: 70958-86-0
- Formula:C18H25ClN2O5S
- Molecular Weight:416.92
IUPAC Name: 5-(1-hydroxy-2-((2-(2-methoxyphenoxy)ethyl)amino)ethyl)-2-methylbenzenesulfonamide hydrochloride
InChIKey: JRVCPDVOFCWKAG-UHFFFAOYSA-N
SMILES: O=S(C1=CC(C(O)CNCCOC2=CC=CC=C2OC)=CC=C1C)(N)=O.Cl
Biological Activity: Amosulalol (YM 09538) hydrochloride is an orally active and dual inhibitor of α1/β1-Adrenergic Receptor. Amosulalol hydrochloride exhibits antihypertensive activity via α1-Adrenergic Receptor inhibition. Amosulalol hydrochloride decreases reflexogenic increases in heart rate and plasma renin activity (PRA) via β1-Adrenergic Receptor inhibition in spontaneously hypertensive rats (SHR)[1].
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Amosulalol hydrochloride | Amosulalol (YM 09538) hydrochloride is an orally active and dual inhibitor of α1/β1-Adrenergic Receptor. Amosulalol hydrochloride exhibits antihypertensive activity via α1-Adrenergic Receptor inhibition. Amosulalol hydrochloride decreases reflexogenic increases in heart rate and plasma renin activity (PRA) via β1-Adrenergic Receptor inhibition in spontaneously hypertensive rats (SHR). | |||||||||||||||||||||
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Keywords
