711019-86-2
711019-86-2
Chemical Structure
MRS 2578
- CAS No.: 711019-86-2
- Formula:C20H20N6S4
- Molecular Weight:472.67
IUPAC Name: 1,1'-(butane-1,4-diyl)bis(3-(3-isothiocyanatophenyl)thiourea)
InChIKey: QOHNRGHTJPFMSL-UHFFFAOYSA-N
SMILES: S=C(NCCCCNC(NC1=CC(N=C=S)=CC=C1)=S)NC2=CC(N=C=S)=CC=C2
Biological Activity: MRS 2578 is a selective and potent P2Y6 receptor antagonist with IC50s of 37 nM (human) and 98 nM (rat). MRS 2578 exhibits insignificant activity at P2Y1, P2Y2, P2Y4, and P2Y11 receptors[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MRS 2578 | 99.50% | MRS 2578 is a selective and potent P2Y6 receptor antagonist with IC50s of 37 nM (human) and 98 nM (rat). MRS 2578 exhibits insignificant activity at P2Y1, P2Y2, P2Y4, and P2Y11 receptors. | ||||||||||||||||||||
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MRS 2578 (Standard) | ≥98% | MRS 2578 (Standard) is the analytical standard of MRS 2578. This product is intended for research and analytical applications. MRS 2578 is a selective and potent P2Y6 receptor antagonist with IC50s of 37 nM (human) and 98 nM (rat). MRS 2578 exhibits insignificant activity at P2Y1, P2Y2, P2Y4, and P2Y11 receptors. | ||||||||||||||||||||
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References
- [1]. Mamedova LK, et al. Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors. Biochem Pharmacol, 2004, 67(9), 1763-1770. [Content Brief]
- [2]. Nishida M, et al. P2Y6 receptor-Galpha12/13 signalling in cardiomyocytes triggers pressure overload-induced cardiacfibrosis. EMBO J. 2008 Dec 3;27(23):3104-15. [Content Brief]
Keywords
