712325-30-9
712325-30-9
Chemical Structure
VU0405601
- CAS No.: 712325-30-9
- Formula:C17H13BrN2O2
- Molecular Weight:357.20
IUPAC Name: 2-((1-bromonaphthalen-2-yl)oxy)-N-(pyridin-3-yl)acetamide
InChIKey: WLLRAGBPCSOJNH-UHFFFAOYSA-N
SMILES: O=C(COC1=CC=C2C=CC=CC2=C1Br)NC3=CC=CN=C3
Biological Activity: VU0405601 is a potent KV11.1 channel activator. VU0405601 protects cardiac tissue from dofetilide (HY-B0232)-induced ventricular tachycardia[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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VU0405601 | 99.93% | VU0405601 is a potent KV11.1 channel activator. VU0405601 protects cardiac tissue from dofetilide (HY-B0232)-induced ventricular tachycardia. | ||||||||||||||||||||
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References
- [1]. Egly CL, et al. A High-Throughput Screening Assay to Identify Drugs that Can Treat Long QT Syndrome Caused by Trafficking-Deficient KV11.1 (hERG) Variants. Mol Pharmacol. 2022 Apr;101(4):236-245. [Content Brief]
- [2]. Potet F, et al. Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmias. J Biol Chem. 2012 Nov 16;287(47):39613-25. [Content Brief]
Keywords
