71939-12-3
Chemical Structure
Aβ aggregation modulator-1
- CAS No.: 71939-12-3
- Formula:C24H15NO7
- Molecular Weight:429.38
IUPAC Name: 2,8-bis(2,4-dihydroxyphenyl)-7-hydroxy-3H-phenoxazin-3-one
InChIKey: VBELMRDAQMYTOU-UHFFFAOYSA-N
SMILES: O=C1C=C2OC3=CC(O)=C(C4=C(O)C=C(O)C=C4)C=C3N=C2C=C1C5=C(O)C=C(O)C=C5
Biological Activity: Aβ aggregation modulator-1 is a stimulator of amyloid-β (Aβ) fibrillogenesis. Aβ aggregation modulator-1 binds hydrophobic residues in Aβ peptides and stabilizes β-sheet-rich protofibrils and fibrils. Aβ aggregation modulator-1 accelerates Aβ polymerization and reduces concentrations of small, toxic Aβ oligomers in heterogeneous aggregation reactions. Aβ aggregation modulator-1 suppresses long-term potentiation (LTP) inhibition by Aβ oligomers in hippocampal brain slices. Aβ aggregation modulator-1 can be used for the study of Alzheimer's disease (AD)[1].
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Aβ aggregation modulator-1 | Aβ aggregation modulator-1 is a stimulator of amyloid-β (Aβ) fibrillogenesis. Aβ aggregation modulator-1 binds hydrophobic residues in Aβ peptides and stabilizes β-sheet-rich protofibrils and fibrils. Aβ aggregation modulator-1 accelerates Aβ polymerization and reduces concentrations of small, toxic Aβ oligomers in heterogeneous aggregation reactions. Aβ aggregation modulator-1 suppresses long-term potentiation (LTP) inhibition by Aβ oligomers in hippocampal brain slices. Aβ aggregation modulator-1 can be used for the study of Alzheimer's disease (AD). | |||||||||||||||||||||
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Keywords
