Aβ aggregation modulator-1
Aβ aggregation modulator-1 is a stimulator of amyloid-β (Aβ) fibrillogenesis. Aβ aggregation modulator-1 binds hydrophobic residues in Aβ peptides and stabilizes β-sheet-rich protofibrils and fibrils. Aβ aggregation modulator-1 accelerates Aβ polymerization and reduces concentrations of small, toxic Aβ oligomers in heterogeneous aggregation reactions. Aβ aggregation modulator-1 suppresses long-term potentiation (LTP) inhibition by Aβ oligomers in hippocampal brain slices. Aβ aggregation modulator-1 can be used for the study of Alzheimer's disease (AD).
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- CAS 番号: 71939-12-3
- 分子式: C24H15NO7
- 分子量:429.38
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Aβ42-IN-6 (Compound O4) (48 h) reduces Aβ42-induced toxicity in differentiated SH-SY5Y cells and primary cortical neurons[1].
Aβ42-IN-6 (5-25 μM; 48 h) promotes aggregation of Aβ42 in SH-SY5Y cell culture media, decreasing the abundance of soluble Aβ42 monomers and small oligomers while increasing larger aggregate structures[1].
Aβ42-IN-6 (5 μM, 48 h) stimulates the formation of SDS-resistant Aβ aggregates in 7PA2 cells (CHO cells overexpressing mutant human APP)[1].
Aβ42-IN-6 suppresses Aβ42- induced inhibition of hippocampal long-term potentiation (LTP) in the CA1 area of rat brain slices, rescuing the dysfunction of synaptic plasticity caused by toxic Aβ42 oligomers[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 71939-12-3
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分子量 429.38
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分子式 C24H15NO7
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SMILES
O=C1C=C2OC3=CC(O)=C(C4=C(O)C=C(O)C=C4)C=C3N=C2C=C1C5=C(O)C=C(O)C=C5
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Aβ aggregation modulator-1 関連分類
HY-13325 関連分類
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