7280-37-7
Chemical Structure
Estropipate
Synonym(s): Piperazine estrone sulfate; Estrone sulfate piperazine salt
- CAS No.: 7280-37-7
- Formula:C22H32N2O5S
- Molecular Weight:436.56
IUPAC Name: piperazine (8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl sulfate
InChIKey: HZEQBCVBILBTEP-ZFINNJDLSA-N
SMILES: C[C@]1([C@](CC2)([H])[C@]3([H])CCC4=C(C=CC(OS(=O)(O)=O)=C4)[C@@]3([H])CC1)C2=O.N5CCNCC5
Biological Activity: Estropipate (Piperazine estrone sulfate; Estrone sulfate piperazine salt) is an inactive endogenous estrogen that can be converted into Estrone (HY-B0234) and Estradiol (HY-B0141). Estropipate is an orally active estrogen receptor α agonist and a selective OATP1B1 inhibitor. Estropipate inhibits OATP1B1-mediated uptake of statin substrates. Estropipate regulates the estrogen signaling pathway and ameliorates sensory processing and arousal-related behavioral deficits in scn1lab-mutant zebrafish. Estropipate can be used in studies related to autism[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Estropipate | 98.72% | Estropipate (Piperazine estrone sulfate; Estrone sulfate piperazine salt) is an inactive endogenous estrogen that can be converted into Estrone (HY-B0234) and Estradiol (HY-B0141). Estropipate is an orally active estrogen receptor α agonist and a selective OATP1B1 inhibitor. Estropipate inhibits OATP1B1-mediated uptake of statin substrates. Estropipate regulates the estrogen signaling pathway and ameliorates sensory processing and arousal-related behavioral deficits in scn1lab-mutant zebrafish. Estropipate can be used in studies related to autism. | ||||||||||||||||||||
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Estropipate (Standard) | ≥98% | Estropipate (Standard) (Piperazine estrone sulfate (Standard); Estrone sulfate piperazine salt (Standard)) is the analytical standard of Estropipate (HY-B1361). This product is intended for research and analytical applications. Estropipate is an inactive endogenous estrogen that can be converted into Estrone (HY-B0234) and Estradiol (HY-B0141). Estropipate is an orally active estrogen receptor α agonist and a selective OATP1B1 inhibitor. Estropipate inhibits OATP1B1-mediated uptake of statin substrates. Estropipate regulates the estrogen signaling pathway and ameliorates sensory processing and arousal-related behavioral deficits in scn1lab-mutant zebrafish. Estropipate can be used in studies related to autism. | ||||||||||||||||||||
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References
- [1]. Jamadagni P, et al. Pharmaco-behavioral profiling identifies suppressors of autism gene-associated phenotypes in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 2026 Mar 24;123(12):e2518846123.
- [2]. Zhang Y, et al. Dissecting the Contribution of OATP1B1 to Hepatic Uptake of Statins Using the OATP1B1 Selective Inhibitor Estropipate. Molecular pharmaceutics. 2019 Jun 03;16(6):2342-2353.
