732973-87-4
Chemical Structure
GOT1 inhibitor-1
- CAS No.: 732973-87-4
- Formula:C19H19ClN4O
- Molecular Weight:354.83
IUPAC Name: N-(4-chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
InChIKey: VVVZKBOSNCHQEJ-UHFFFAOYSA-N
SMILES: O=C(N1CCN(C2=CC=CC3=C2C=CN3)CC1)NC4=CC=C(Cl)C=C4
Biological Activity: GOT1 inhibitor-1 (compound 2c), a tryptamine-based derivative, acts as a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC50 of 8.2 uM. GOT1 plays an important role in energy metabolism and Reactive Oxygen Species (ROS) balance. GOT1 inhibitor-1 can be used for the research of pancreatic ductal adenocarcinoma (PDAC)[1].
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GOT1 inhibitor-1 | 98.75% | GOT1 inhibitor-1 (compound 2c), a tryptamine-based derivative, acts as a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC50 of 8.2 uM. GOT1 plays an important role in energy metabolism and Reactive Oxygen Species (ROS) balance. GOT1 inhibitor-1 can be used for the research of pancreatic ductal adenocarcinoma (PDAC). | ||||||||||||||||||||
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Keywords
