745055-91-8
745055-91-8
Chemical Structure
UBP 302
- CAS No.: 745055-91-8
- Formula:C15H15N3O6
- Molecular Weight:333.30
IUPAC Name: (S)-2-((3-(2-amino-2-carboxyethyl)-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)methyl)benzoic acid
InChIKey: UUIYULWYHDSXHL-NSHDSACASA-N
SMILES: O=C(N(C=CC1=O)C[C@H](N)C(O)=O)N1CC2=C(C=CC=C2)C(O)=O
Biological Activity: UBP 302 is a potent and selective GLUK5-subunit containing kainate receptor antagonist (apparent Kd=402 nM), and displays very little affinity on GluK2 (GluR6) kainate receptors. Anxiolytic effects[1][2][3].
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UBP 302 | 99.75% | UBP 302 is a potent and selective GLUK5-subunit containing kainate receptor antagonist (apparent Kd=402 nM), and displays very little affinity on GluK2 (GluR6) kainate receptors. Anxiolytic effects. | ||||||||||||||||||||
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References
- [1]. More JC, et al. Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist. Neuropharmacology. 2004 Jul;47(1):46-64. [Content Brief]
- [2]. Dolman NP, et al. Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors. J Med Chem. 2005 Dec 1;48(24):7867-81. [Content Brief]
- [3]. Apland JP, et al. The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302. J Pharmacol Exp Ther. 2014 Nov;351(2):359-72. [Content Brief]
Keywords
