754998-88-4
754998-88-4
Chemical Structure
TIC10g
- CAS No.: 754998-88-4
- Formula:C20H21N3O4
- Molecular Weight:367.40
InChIKey: AKQCUNWVVQYIIO-UHFFFAOYSA-N
SMILES: CN1C(C2=CC=C3C(OCO3)=C2)=CN=C1NCC4=C(OC)C=C(OC)C=C4
Biological Activity: TIC10g is a dual inhibitor for toll-like receptor 7 and 9 (TLR7 and TLR9), which inhibits TLR7 and TLR9 mediated TNF-α release in mouse macrophages (IC50 is 14.5 μM and 6.5 μM) and human B lymphocytes (IC50 is 7.69 μM and 11.5 μM). TIC10g inhibits the activation of NF-κB and MAPK, and exhibits anti-inflammatory activity against systemic lupus erythematosus and rheumatoid arthritis [1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
TIC10g | 98.92% | TIC10g is a dual inhibitor for toll-like receptor 7 and 9 (TLR7 and TLR9), which inhibits TLR7 and TLR9 mediated TNF-α release in mouse macrophages (IC50 is 14.5 μM and 6.5 μM) and human B lymphocytes (IC50 is 7.69 μM and 11.5 μM). TIC10g inhibits the activation of NF-κB and MAPK, and exhibits anti-inflammatory activity against systemic lupus erythematosus and rheumatoid arthritis . | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
