75580-37-9
Chemical Structure
Luzopeptin A
Synonym(s): BBM-928 A
- CAS No.: 75580-37-9
- Formula:C64H78N14O24
- Molecular Weight:1427.38
IUPAC Name: (4S,4aS,13S,17R,23S,23aS,32S,36R)-17,36-bis(3-hydroxy-6-methoxyquinoline-2-carboxamido)-13,32-bis(2-hydroxypropan-2-yl)-9,12,28,31-tetramethyl-5,8,11,14,18,24,27,30,33,37-decaoxo-4,4a,5,6,7,8,9,10,11,12,13,14,17,18,23,23a,24,25,26,27,28,29,30,31,32,33,36,
InChIKey: QMZVWFQMMLKHLS-LPQVFZKKSA-N
SMILES: O=C1N2[C@@](C(NCC(N(CC(N([C@H](C(OC[C@H](C(N3[C@]([C@H](CC=N3)OC(C)=O)([H])C(NCC(N(CC(N([C@H](C(OC[C@H]1NC(C4=NC5=C(C=C(C=C5)OC)C=C4O)=O)=O)C(C)(O)C)C)=O)C)=O)=O)=O)NC(C6=NC7=C(C=C(C=C7)OC)C=C6O)=O)=O)C(C)(O)C)C)=O)C)=O)=O)([H])[C@H](CC=N2)OC(C)=O
Biological Activity: Luzopeptin A (BBM-928 A) is an actinoleukin-like antitumor antibiotic. Luzopeptin A is a bifunctional DNA intercalator which can interact with isolated DNA molecules. Luzopeptin A induces an unwinding-rewinding process of the closed superhelical PM2 DNA. Luzopeptin A is active against HIV-1 and HIV-2 reverse transcriptase with IC50s of 7 nM and 68 nM for HIV-1 RT and HIV-2 RT, respectively[1][2].
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Luzopeptin A | Luzopeptin A (BBM-928 A) is an actinoleukin-like antitumor antibiotic. Luzopeptin A is a bifunctional DNA intercalator which can interact with isolated DNA molecules. Luzopeptin A induces an unwinding-rewinding process of the closed superhelical PM2 DNA. Luzopeptin A is active against HIV-1 and HIV-2 reverse transcriptase with IC50s of 7 nM and 68 nM for HIV-1 RT and HIV-2 RT, respectively. | |||||||||||||||||||||
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Keywords
