77-41-8
77-41-8
Chemical Structure
Methsuximide
Synonym(s): Mesuximide; Celontin
- CAS No.: 77-41-8
- Formula:C12H13NO2
- Molecular Weight:203.24
IUPAC Name: 1,3-dimethyl-3-phenylpyrrolidine-2,5-dione
InChIKey: AJXPJJZHWIXJCJ-UHFFFAOYSA-N
SMILES: O=C(C(C1=CC=CC=C1)(C)C2)N(C)C2=O
Biological Activity: Methsuximide (Mesuximide) is an orally active succinimide-derived antiepileptic agent. Methsuximide interacts with cytochrome P-450, increases the level of hepatic microsomal cytochrome P-450, and inhibits or competes with the cytochrome P-450 CYP 2C9/10 subtype. Methsuximide can be used in epilepsy-related research[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Methsuximide | 99.83% | Methsuximide (Mesuximide) is an orally active succinimide-derived antiepileptic agent. Methsuximide interacts with cytochrome P-450, increases the level of hepatic microsomal cytochrome P-450, and inhibits or competes with the cytochrome P-450 CYP 2C9/10 subtype. Methsuximide can be used in epilepsy-related research. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Methsuximide (Standard) | ≥98% | Methsuximide (Standard) (Mesuximide (Standard); Celontin (Standard)) is the analytical standard of Methsuximide (HY-B1376). This product is intended for research and analytical applications. Methsuximide (Mesuximide) is an orally active succinimide-derived antiepileptic agent. Methsuximide interacts with cytochrome P-450, increases the level of hepatic microsomal cytochrome P-450, and inhibits or competes with the cytochrome P-450 CYP 2C9/10 subtype. Methsuximide can be used in epilepsy-related research. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Methsuximide-d5 | Methsuximide-d5 is the deuterated-labeled Methsuximide (HY-B1376). Methsuximide (Mesuximide) is an orally active succinimide-derived antiepileptic agent. Methsuximide interacts with cytochrome P-450, increases the level of hepatic microsomal cytochrome P-450, and inhibits or competes with the cytochrome P-450 CYP 2C9/10 subtype. Methsuximide can be used in epilepsy-related research. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Pheneturide (Standard) | 99.84% | Pheneturide (Ethylphenacemide; M 551) (Standard) is the analytical standard of Pheneturide (HY-111177). This product is intended for research and analytical applications. Pheneturide (Ethylphenacemide; M 551) is an orally active anticonvulsant. Pheneturide is a decarboxylation product of 5-ethyl-5-phenylbarbituric acid, with antiepileptic and central inhibitory effects. Pheneturide has protective effects against both MES tonic convulsions and Metrazol clonic convulsions. Pheneturide prolongs sedative-induced sleep, increases spontaneous locomotor activity, and inhibits fighting behavior. Pheneturide can be used in epilepsy-related research. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Nebracetam | Nebracetam (WEB 1881 FU) is an orally active M1 muscarinic receptor agonist. Nebracetam can induce an increase in intracellular Ca2+ concentration, with an EC50 value of 1.59 mM. Nebracetam exhibits neuroprotective activity and the ability to improve cognitive impairment. Nebracetam can be used in the research of neurological diseases such as Alzheimer's disease. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Brosuximide | Brosuximide is a succinimide-type antiepileptic agent. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
E3 ligase Ligand PG | 99.94% | E3 ligase Ligand PG is an E3 ligase CRBN ligand with an IC50 of 2.191 μM. E3 ligase Ligand PG can be connected to BMS-202 (HY-19745) via a linker to form the PROTAC PROTAC PD-L1 degrader-1 (HY-163757). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Taltobulin intermediate-2 | 95.12% | Taltobulin intermediate-2 is an intermediate in the synthesis of Taltobulin (HY-15584). Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Phensuximide | 99.41% | Phensuximide is an orally active succinimide antiepileptic and anticonvulsant agent. Phensuximide inhibits cyclic AMP and cyclic GMP accumulation in depolarized brain tissue. Phensuximide can be used for the study of seizure and petit mal. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
1-Phenylcyclopentanecarboxylic acid (Standard) | ≥98% | 1-Phenylcyclopentanecarboxylic acid (Standard) is the analytical standard of 1-Phenylcyclopentanecarboxylic acid. This product is intended for research and analytical applications. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
4-Phenyl-2-pyrrolidinone | 99.93% | 4-Phenyl-2-pyrrolidinone is a precursor and synthetic intermediate. 4-Phenyl-2-pyrrolidinone can be used as a precursor in the synthesis of compounds with anticonvulsant and nootropic activities and is an intermediate in the synthesis of bromodomain-containing protein 4 (BRD4) bromodomain 1 inhibitors. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
4-(4-Chlorophenyl)pyrrolidin-2-one (Standard) | ≥98% | 4-(4-Chlorophenyl)pyrrolidin-2-one (Standard) is the analytical standard of 4-(4-Chlorophenyl)pyrrolidin-2-one. This product is intended for research and analytical applications. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Orton TC, et al. Effect in rats of subacute administration of ethosuximide, methsuximide and phensuximide on hepatic microsomal enzymes and porphyrin turnover. Biochem Pharmacol. 1972 Aug 15;21(16):2253-61. [Content Brief]
- [2]. CHEN G, et al. Anticonvulsant activity and toxicity of phensuximide, methsuximide and ethosuximide. Epilepsia. 1963 Mar;4:66-76.
- [3]. Sigler M, et al. Effective and safe but forgotten: methsuximide in intractable epilepsies in childhood. Seizure. 2001 Mar;10(2):120-4. [Content Brief]
- [4]. Besag FM, et al. Methsuximide lowers lamotrigine blood levels: A pharmacokinetic antiepileptic drug interaction. Epilepsia. 2000 May;41(5):624-7. [Content Brief]
- [5]. Dobrinska MR, et al. Pharmacokinetics of methsuximide and a major metabolite in dogs. Journal of pharmaceutical sciences. 1977 May;66(5):688-92. [Content Brief]
