Methsuximide-d5
Methsuximide-d5 is the deuterated-labeled Methsuximide (HY-B1376). Methsuximide (Mesuximide) is an orally active succinimide-derived antiepileptic agent. Methsuximide interacts with cytochrome P-450, increases the level of hepatic microsomal cytochrome P-450, and inhibits or competes with the cytochrome P-450 CYP 2C9/10 subtype. Methsuximide can be used in epilepsy-related research.
For research use only. We do not sell to patients.
- CAS No.: 1189980-63-9
- Formula: C12H8D5NO2
- Molecular Weight:208.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1189980-63-9
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Unlabeled CAS 77-41-8
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Molecular Weight 208.27
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Formula C12H8D5NO2
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SMILES
CC1(C(=O)N(C)C(=O)C1)C2=C(C(=C(C(=C2[2H])[2H])[2H])[2H])[2H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Orton TC, et al. Effect in rats of subacute administration of ethosuximide, methsuximide and phensuximide on hepatic microsomal enzymes and porphyrin turnover. Biochem Pharmacol. 1972 Aug 15;21(16):2253-61. [Content Brief]
[3]. Sigler M, et al. Effective and safe but forgotten: methsuximide in intractable epilepsies in childhood. Seizure. 2001 Mar;10(2):120-4. [Content Brief]
[4]. Besag FM, et al. Methsuximide lowers lamotrigine blood levels: A pharmacokinetic antiepileptic drug interaction. Epilepsia. 2000 May;41(5):624-7. [Content Brief]
[5]. Dobrinska MR, et al. Pharmacokinetics of methsuximide and a major metabolite in dogs. Journal of pharmaceutical sciences. 1977 May;66(5):688-92. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Methsuximide-d5 Related Classifications
HY-132399S Related Classifications
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Keywords
- Methsuximide-d5
- 1189980-63-9
- Isotope-Labeled Compounds
- Cytochrome P450
- pentylenetetrazol-induced clonic seizures
- Sprague-Dawley rats
- CFHB Wistar rat liver microsomes
- Macaca rhesus monkeys
- cytochrome P-450
- chick embryo liver
- Webster strain mice
- electroshock-induced tonic extensor seizures
- CYP 2C9/10 isoform
- δ-aminolaevulinic acid synthetase
- Inhibitor
- inhibitor
- inhibit