77145-61-0
77145-61-0
Chemical Structure
SR 57227A
- CAS No.: 77145-61-0
- Formula:C10H15Cl2N3
- Molecular Weight:248.15
IUPAC Name: 1-(6-chloropyridin-2-yl)piperidin-4-amine hydrochloride
InChIKey: FUMINTAAUJUVMP-UHFFFAOYSA-N
SMILES: ClC1=NC(N2CCC(N)CC2)=CC=C1.[H]Cl
Biological Activity: SR 57227A is a potent, orally active and selective 5-HT3 receptor agonist, with ability to cross the blood brain barrier. SR 57227A has affinities (IC50) varying between 2.8 and 250 nM for 5-HT3 receptor binding sites in rat cortical membranes and on whole NG 108-15 cells or their membranes. Anti-depressant effects[1][2].
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SR 57227A | 99.86% | SR 57227A is a potent, orally active and selective 5-HT3 receptor agonist, with ability to cross the blood brain barrier. SR 57227A has affinities (IC50) varying between 2.8 and 250 nM for 5-HT3 receptor binding sites in rat cortical membranes and on whole NG 108-15 cells or their membranes. Anti-depressant effects. | ||||||||||||||||||||
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SR 57227A (Standard) | ≥98% | SR 57227A (Standard) is the analytical standard of SR 57227A (HY-102064). This product is intended for research and analytical applications. SR 57227A is a potent, orally active and selective 5-HT3 receptor agonist, with ability to cross the blood brain barrier. SR 57227A has affinities (IC50) varying between 2.8 and 250 nM for 5-HT3 receptor binding sites in rat cortical membranes and on whole NG 108-15 cells or their membranes. Anti-depressant effects. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.97
HY-121704SR 57227A free base -
Similarity Score 0.88
HY-184316CM 57373 -
Similarity Score 0.76
HY-101100Anpirtoline hydrochloride -
Similarity Score 0.76
HY-101324AMK-212 monohydrochloride -
Similarity Score 0.75
HY-101324MK-212 -
Similarity Score 0.74
HY-101100AAnpirtoline -
Similarity Score 0.74
HY-Y0889A1-(2,3-Dichlorphenyl)piperazine hydrochloride -
Similarity Score 0.73
HY-42543Ribociclib impurity 3 -
Similarity Score 0.72
HY-Z11110Aripiprazole impurity 28 -
Explore the MedChemAI to find more analogs
References
- [1]. Poncelet M, et al, Le Fur G. Antidepressant-like effects of SR 57227A, a 5-HT3 receptor agonist, in rodents. J Neural Transm Gen Sect. 1995;102(2):83‐90. [Content Brief]
- [2]. Bachy A, et al. SR 57227A: a potent and selective agonist at central and peripheral 5-HT3 receptors in vitro and in vivo. Eur J Pharmacol. 1993;237(2-3):299‐309. [Content Brief]
