Anpirtoline
Anpirtoline (D-16949) is a centrally acting 5-HT1B receptor agonist, with Kis of 28 nM (5-HT1B), 150 nM (5-HT1A) and 1.49 μM (5-HT2). Anpirtoline has serotonergic, antinociceptive, antidepressant-like effects.
For research use only. We do not sell to patients.
- CAS No.: 98330-05-3
- Formula: C10H13ClN2S
- Molecular Weight:228.74
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All 5-HT Receptor Isoforms
More
Biological Activity
|
5-HT1A Receptor |
5-HT1B Receptor |
Chemical Information
-
CAS No. 98330-05-3
-
Molecular Weight 228.74
-
Formula C10H13ClN2S
-
SMILES
ClC1=NC(SC2CCNCC2)=CC=C1
-
Synonyms
D-16949
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Swedberg MD, et al. D-16949 (anpirtoline): a novel serotonergic (5-HT1B) psychotherapeutic agent assessed by its discriminative effects in the rat. J Pharmacol Exp Ther. 1992 Dec;263(3):1015-22. [Content Brief]
[2]. Chien PY, et al. The dorsal raphe-to-ventral hippocampal projection modulates reactive aggression through 5-HT1B receptors. Eur J Pharmacol. 2024 Oct 15;981:176918. [Content Brief]
[3]. Schlicker E, et al. Anpirtoline, a novel, highly potent 5-HT1B receptor agonist with antinociceptive/antidepressant-like actions in rodents. Br J Pharmacol. 1992 Mar;105(3):732-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz