98330-05-3
98330-05-3
Chemical Structure
Anpirtoline
Synonym(s): D-16949
- CAS No.: 98330-05-3
- Formula:C10H13ClN2S
- Molecular Weight:228.74
IUPAC Name: 2-chloro-6-(piperidin-4-ylthio)pyridine
InChIKey: GGALEXMXDMUMDM-UHFFFAOYSA-N
SMILES: ClC1=NC(SC2CCNCC2)=CC=C1
Biological Activity: Anpirtoline (D-16949) is a centrally acting 5-HT1B receptor agonist, with Kis of 28 nM (5-HT1B), 150 nM (5-HT1A) and 1.49 μM (5-HT2). Anpirtoline has serotonergic, antinociceptive, antidepressant-like effects[1][2][3].
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Anpirtoline | Anpirtoline (D-16949) is a centrally acting 5-HT1B receptor agonist, with Kis of 28 nM (5-HT1B), 150 nM (5-HT1A) and 1.49 μM (5-HT2). Anpirtoline has serotonergic, antinociceptive, antidepressant-like effects. | |||||||||||||||||||||
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References
- [1]. Swedberg MD, et al. D-16949 (anpirtoline): a novel serotonergic (5-HT1B) psychotherapeutic agent assessed by its discriminative effects in the rat. J Pharmacol Exp Ther. 1992 Dec;263(3):1015-22. [Content Brief]
- [2]. Chien PY, et al. The dorsal raphe-to-ventral hippocampal projection modulates reactive aggression through 5-HT1B receptors. Eur J Pharmacol. 2024 Oct 15;981:176918. [Content Brief]
- [3]. Schlicker E, et al. Anpirtoline, a novel, highly potent 5-HT1B receptor agonist with antinociceptive/antidepressant-like actions in rodents. Br J Pharmacol. 1992 Mar;105(3):732-8. [Content Brief]
Keywords
