78846-91-0
78846-91-0
Chemical Structure
Norzotepine
- CAS No.: 78846-91-0
- Formula:C17H16ClNOS
- Molecular Weight:317.83
IUPAC Name: 2-((8-chlorodibenzo[b,f]thiepin-10-yl)oxy)-N-methylethan-1-amine
InChIKey: OVVBIIBBRZVPAL-UHFFFAOYSA-N
SMILES: ClC=1C=CC=2SC=3C=CC=CC3C=C(OCCNC)C2C1
Biological Activity: Norzotepine is the major human metabolite of Zotepine (HY-103093) and also a NET inhibitor (human IC50 = 4.2 nM). Norzotepine exerts antipsychotic-like and antidepressant-like effects by inhibiting Norepinephrine (HY-13715) reuptake and blocking dopamine D2 (Dopamine D2), histamine H1 (Histamine H1), and 5-HT2 receptors. Norzotepine can be used for research on schizophrenia[1][2][3][4].
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Norzotepine | Norzotepine is the major human metabolite of Zotepine (HY-103093) and also a NET inhibitor (human IC50 = 4.2 nM). Norzotepine exerts antipsychotic-like and antidepressant-like effects by inhibiting Norepinephrine (HY-13715) reuptake and blocking dopamine D2 (Dopamine D2), histamine H1 (Histamine H1), and 5-HT2 receptors. Norzotepine can be used for research on schizophrenia. | |||||||||||||||||||||
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References
- [1]. Marcus MM, et al. Augmentation by escitalopram, but not citalopram or R-citalopram, of the effects of low-dose risperidone: behavioral, biochemical, and electrophysiological evidence. Synapse (New York, N.Y.). 2012 Apr;66(4):277-90.
- [2]. Shobo M, et al. Norzotepine, a major metabolite of zotepine, exerts atypical antipsychotic-like and antidepressant-like actions through its potent inhibition of norepinephrine reuptake. The Journal of pharmacology and experimental therapeutics. 2010 Jun;333(3):772-81.
- [3]. Barnas C, et al. In vivo (123)I IBZM SPECT imaging of striatal dopamine 2 receptor occupancy in schizophrenic patients. Psychopharmacology. 2001 Sep;157(3):236-42.
- [4]. Liégeois JF, et al. New pyridobenzoxazepine derivatives derived from 5-(4-methylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5]benzoxazepine (JL13): chemical synthesis and pharmacological evaluation. Journal of medicinal chemistry. 2012 Feb 23;55(4):1572-82.
