79781-00-3
79781-00-3
Chemical Structure
Bulaquine
Synonym(s): CDRI 80/53; Elubaquine
- CAS No.: 79781-00-3
- Formula:C21H27N3O3
- Molecular Weight:369.46
IUPAC Name: (Z)-3-(1-((4-((6-methoxyquinolin-8-yl)amino)pentyl)amino)ethylidene)dihydrofuran-2(3H)-one
InChIKey: ADCOUXIGWFEYJP-SDXDJHTJSA-N
SMILES: C/C(NCCCC(NC1=CC(OC)=CC2=C1N=CC=C2)C)=C3C(OCC/3)=O
Biological Activity: Bulaquine (CDRI 80/53) is a potent antimalarial agent which is an analogue of Primaquine (HY-12651A). Bulaquine affects multiple metabolism pathways and shows inhibition effect on Plasmodium cynomolgi infection. Bulaquine can be used for the research of malaria[1][2][3].
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Bulaquine | Bulaquine (CDRI 80/53) is a potent antimalarial agent which is an analogue of Primaquine (HY-12651A). Bulaquine affects multiple metabolism pathways and shows inhibition effect on Plasmodium cynomolgi infection. Bulaquine can be used for the research of malaria. | |||||||||||||||||||||
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References
- [1]. Noel S, et al. Identification of differentially expressed genes after acute exposure to bulaquine (CDRI 80/53) in mice liver. Basic Clin Pharmacol Toxicol. 2008 Dec;103(6):522-9. [Content Brief]
- [2]. Dutta GP, et al. Radical curative activity of a new 8-aminoquinoline derivative (CDRI 80/53) against Plasmodium cynomolgi B in monkeys. Am J Trop Med Hyg. 1989 Dec;41(6):635-7. [Content Brief]
- [3]. Wells TN, et al. Targeting the hypnozoite reservoir of Plasmodium vivax: the hidden obstacle to malaria elimination. Trends Parasitol. 2010 Mar;26(3):145-51.Wells TN, et al. Targeting the hypnozoite reservoir of Plasmodium vivax: the hidden obstacle to malaria elimination. Trends Parasitol. 2010 Mar;26(3):145-51. [Content Brief]
