80427-58-3
Chemical Structure
Benfluron hydrochloride
Synonym(s): Benflurone hydrochloride
- CAS No.: 80427-58-3
- Formula:C21H20ClNO2
- Molecular Weight:353.84
IUPAC Name: 5-(2-(dimethylamino)ethoxy)-7H-benzo[c]fluoren-7-one hydrochloride
InChIKey: FEDBYSNFQHOGCJ-UHFFFAOYSA-N
SMILES: O=C1C2=C(C3=C1C=C(OCCN(C)C)C4=C3C=CC=C4)C=CC=C2.Cl
Biological Activity: Benfluron hydrochloride is an Apoptosis inducer and inhibitor of the HIV-1 Rev-RRE complex, with an IC50 of 5.0 μM against the HIV-1 Rev-RRE complex. Benfluron hydrochloride induces p53 activation, and triggers phosphorylation of Chk1 at serine 345, Chk2 at threonine 68, as well as ERK1/2 at threonine 202 and tyrosine 204. Benfluron hydrochloride activates Caspase 8, Caspase 9 and Caspase 3/7, inhibits HIV-1 viral transcription, and acts as a substrate for 11β-HSD 1 and cytosolic carbonyl reductase. Benfluron hydrochloride can be used in research related to leukemia and HIV-1 infection[1][2][3].
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Benfluron hydrochloride | Benfluron hydrochloride is an Apoptosis inducer and inhibitor of the HIV-1 Rev-RRE complex, with an IC50 of 5.0 μM against the HIV-1 Rev-RRE complex. Benfluron hydrochloride induces p53 activation, and triggers phosphorylation of Chk1 at serine 345, Chk2 at threonine 68, as well as ERK1/2 at threonine 202 and tyrosine 204. Benfluron hydrochloride activates Caspase 8, Caspase 9 and Caspase 3/7, inhibits HIV-1 viral transcription, and acts as a substrate for 11β-HSD 1 and cytosolic carbonyl reductase. Benfluron hydrochloride can be used in research related to leukemia and HIV-1 infection. | |||||||||||||||||||||
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References
- [1]. Seifrtová M, et al. Benfluron Induces Cell Cycle Arrest, Apoptosis and Activation of p53 Pathway in MOLT-4 Leukemic Cells. Folia biologica. 2015;61(4):147-55. [Content Brief]
- [2]. Chumillas S, et al. Exploring the HIV-1 Rev Recognition Element (RRE)-Rev Inhibitory Capacity and Antiretroviral Action of Benfluron Analogs. Molecules (Basel, Switzerland). 2023 Oct 11;28(20):7031. [Content Brief]
- [3]. Skálová L, et al. Carbonyl reduction of the potential cytostatic drugs benfluron and 3,9-dimethoxybenfluron in human in vitro. Biochemical pharmacology. 2002 Jul 15;64(2):297-305. [Content Brief]
