81338-23-0
Chemical Structure
D-AP7
- CAS No.: 81338-23-0
- Formula:C7H16NO5P
- Molecular Weight:225.18
IUPAC Name: (R)-2-amino-7-phosphonoheptanoic acid
InChIKey: MYDMWESTDPJANS-ZCFIWIBFSA-N
SMILES: OC([C@H](N)CCCCCP(O)(O)=O)=O
Biological Activity: D-AP7 is a specific NMDA receptor antagonist with inhibitory activity against epileptiform activity. D-AP7 attenuated neuronal activation in spot activity by reducing the duration and number of exogenously induced bursts. D-AP7 also increased the amplitude of secondary action potentials, which may restore neuronal activity in some epileptiform bursts. D-AP7 showed anxiogenic effects and impaired memory consolidation in passive avoidance learning[1].
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D-AP7 | D-AP7 is a specific NMDA receptor antagonist with inhibitory activity against epileptiform activity. D-AP7 attenuated neuronal activation in spot activity by reducing the duration and number of exogenously induced bursts. D-AP7 also increased the amplitude of secondary action potentials, which may restore neuronal activity in some epileptiform bursts. D-AP7 showed anxiogenic effects and impaired memory consolidation in passive avoidance learning. | |||||||||||||||||||||
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Keywords
