820244-38-0
Chemical Structure
MGS 0210
Synonym(s): BCI 838
- CAS No.: 820244-38-0
- Formula:C22H28Cl2FNO5
- Molecular Weight:476.37
IUPAC Name: (1R,2R,3R,5R,6R)-2-amino-3-((3,4-dichlorobenzyl)oxy)-6-fluoro-6-((heptyloxy)carbonyl)bicyclo[3.1.0]hexane-2-carboxylic acid
InChIKey: SVZJNGHWEHDHLT-OUSKECTQSA-N
SMILES: CCCCCCCOC([C@@]1([C@]2([H])[C@@]1([H])C[C@@H](OCC3=CC(Cl)=C(Cl)C=C3)[C@@]2(N)C(O)=O)F)=O
Biological Activity: MGS 0210 (BCI 838) is an orally active metabolite of glutamate receptor 2/3 (mGluR2/3) agonists. MGS 0210 improves amnesia and reduces anxiety in APP mice. MGS 0210 improves PTSD-related behaviors in a mouse model of post-traumatic stress disorder (PTSD). MGS 0210 can be used in research on neurological disorders such as Alzheimer's disease and major depressive disorder[1][2].
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MGS 0210 | MGS 0210 (BCI 838) is an orally active metabolite of glutamate receptor 2/3 (mGluR2/3) agonists. MGS 0210 improves amnesia and reduces anxiety in APP mice. MGS 0210 improves PTSD-related behaviors in a mouse model of post-traumatic stress disorder (PTSD). MGS 0210 can be used in research on neurological disorders such as Alzheimer's disease and major depressive disorder. | |||||||||||||||||||||
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- [1]. Kim SH, et al.. Proneurogenic Group II mGluR antagonist improves learning and reduces anxiety in Alzheimer Aβ oligomer mouse. Mol Psychiatry. 2014 Nov;19(11):1235-42. [Content Brief]
- [2]. Tschiffely AE,et al. Blast-induced "PTSD": Evidence from an animal model. Neuropharmacology. 2019 Feb;145(Pt B):220-229. [Content Brief]
Keywords
