MGS 0210
MGS 0210 (BCI 838) is an orally active metabolite of glutamate receptor 2/3 (mGluR2/3) agonists. MGS 0210 improves amnesia and reduces anxiety in APP mice. MGS 0210 improves PTSD-related behaviors in a mouse model of post-traumatic stress disorder (PTSD). MGS 0210 can be used in research on neurological disorders such as Alzheimer's disease and major depressive disorder.
For research use only. We do not sell to patients.
- CAS No.: 820244-38-0
- Formula: C22H28Cl2FNO5
- Molecular Weight:476.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 820244-38-0
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Molecular Weight 476.37
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Formula C22H28Cl2FNO5
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SMILES
CCCCCCCOC([C@@]1([C@]2([H])[C@@]1([H])C[C@@H](OCC3=CC(Cl)=C(Cl)C=C3)[C@@]2(N)C(O)=O)F)=O
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Synonyms
BCI 838
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Kim SH, et al.. Proneurogenic Group II mGluR antagonist improves learning and reduces anxiety in Alzheimer Aβ oligomer mouse. Mol Psychiatry. 2014 Nov;19(11):1235-42. [Content Brief]
[2]. Tschiffely AE,et al. Blast-induced "PTSD": Evidence from an animal model. Neuropharmacology. 2019 Feb;145(Pt B):220-229. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MGS 0210 Related Classifications
HY-108041 Related Classifications
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