82668-33-5
Chemical Structure
U-99194
Synonym(s): U-99194A free base; PNU-99194A; JPC-211
- CAS No.: 82668-33-5
- Formula:C17H27NO2
- Molecular Weight:277.40
IUPAC Name: 5,6-dimethoxy-N,N-dipropyl-2,3-dihydro-1H-inden-2-amine
InChIKey: UOLJKAPABHXFRE-UHFFFAOYSA-N
SMILES: CCCN(CCC)C1CC2=C(C=C(OC)C(OC)=C2)C1
Biological Activity: U-99194 (PNU-99194) is a selective, potent dopamine D3 receptor antagonist. U-99194 inhibits the activation of D3 receptor mediated by endogenously released dopamine or exogenous D3 agonists. U-99194 abrogates the IPSC-suppressive effect of the D3 agonist PD 128907 in rat hippocampal slices. U-99194 significantly suppresses Nicotine (HY-127019)-induced tremor in mice. U-99194 can be used for the study of dopamine D3 receptor-mediated motor disorders, particularly kinetic tremors[1][2].
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U-99194 | U-99194 (PNU-99194) is a selective, potent dopamine D3 receptor antagonist. U-99194 inhibits the activation of D3 receptor mediated by endogenously released dopamine or exogenous D3 agonists. U-99194 abrogates the IPSC-suppressive effect of the D3 agonist PD 128907 in rat hippocampal slices. U-99194 significantly suppresses Nicotine (HY-127019)-induced tremor in mice. U-99194 can be used for the study of dopamine D3 receptor-mediated motor disorders, particularly kinetic tremors. | |||||||||||||||||||||
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References
- [1]. Kato M, et al. Mechanisms Underlying Dopaminergic Regulation of Nicotine-Induced Kinetic Tremor. Front Pharmacol. 2022 Jun 16;13:938175. [Content Brief]
- [2]. Hammad H, et al. Dopamine-mediated disinhibition in the CA1 region of rat hippocampus via D3 receptor activation. J Pharmacol Exp Ther. 2006 Jan;316(1):113-20. [Content Brief]
