83440-03-3
83440-03-3
Chemical Structure
SG-209
- CAS No.: 83440-03-3
- Formula:C10H12N2O3
- Molecular Weight:208.21
IUPAC Name: 2-(nicotinamido)ethyl acetate
InChIKey: JQICNNKLTFYSLS-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CN=C1)NCCOC(C)=O
Biological Activity: SG-209 is a Nicorandil (HY-B0341) derivative that produces relaxation through potassium channel activation, while this action contributes to the vasodilating action of Nicorandil (HY-B0341) at higher concentrations. SG-209 dilates tracheal smooth muscle and increases tracheal blood flow in anesthetized dogs[1][2].
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SG-209 | SG-209 is a Nicorandil (HY-B0341) derivative that produces relaxation through potassium channel activation, while this action contributes to the vasodilating action of Nicorandil (HY-B0341) at higher concentrations. SG-209 dilates tracheal smooth muscle and increases tracheal blood flow in anesthetized dogs. | |||||||||||||||||||||
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References
- [1]. Ishibashi T, et al. 2-Nicotinamidoethyl acetate (SG-209) is a potassium channel opener: structure activity relationship among nicorandil derivatives. Naunyn Schmiedebergs Arch Pharmacol. 1991 Aug;344(2):235-9. [Content Brief]
- [2]. Yonekura H, et al. Effects of N-(2-hydroxyethyl)nicotinamide nitrate (nicorandil; SG-75) and its derivatives on pancreatic exocrine secretion in the dog. Pancreas. 1990;5(1):75-81. [Content Brief]
