84226-14-2
Chemical Structure
FLA-797
- CAS No.: 84226-14-2
- Formula:C15H21BrN2O3
- Molecular Weight:357.24
InChIKey: PWEZBNRZEHPIIQ-JTQLQIEISA-N
SMILES: CCN(CCC1)[C@@H]1CNC(C2=C(C=CC(Br)=C2O)OC)=O
Biological Activity: FLA-797 is a brain-penetrant dopamine D2 receptor blocker and very low affinity for dopamine D1 receptors. FLA-797 selectively binds to and blocks postsynaptic dopamine D2 receptors. FLA-797 induces catalepsy in male rats. FLA-797 blocks dopamine agonist-induced hypothermia in male rats. FLA-797 contributes marginally to the dopamine D2 receptor-blocking activity of Remoxipride (HY-101313) in male rats. FLA-797 does not mimic the atypical antipsychotic profile of Remoxipride. FLA-797 can be used for research on mental disorders[1][2].
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FLA-797 | FLA-797 is a brain-penetrant dopamine D2 receptor blocker and very low affinity for dopamine D1 receptors. FLA-797 selectively binds to and blocks postsynaptic dopamine D2 receptors. FLA-797 induces catalepsy in male rats. FLA-797 blocks dopamine agonist-induced hypothermia in male rats. FLA-797 contributes marginally to the dopamine D2 receptor-blocking activity of Remoxipride (HY-101313) in male rats. FLA-797 does not mimic the atypical antipsychotic profile of Remoxipride. FLA-797 can be used for research on mental disorders. | |||||||||||||||||||||
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References
- [1]. Nilsson LB, et al. Optimization of a peak compression system for a remoxipride metabolite (FLA797) and its application to bioanalysis. J Chromatogr. 1992;591(1-2):207-217. [Content Brief]
- [2]. Ogren SO, et al. Effects of remoxipride's metabolites on dopamine D2 receptors and receptor functions in the rat. Pharmacol Toxicol. 1993;73(6):325-334. [Content Brief]
