845811-30-5
845811-30-5
Chemical Structure
Tonantzitlolone
- CAS No.: 845811-30-5
- Formula:C26H40O7
- Molecular Weight:464.59
InChIKey: YMEAIOHYSIGDJY-VCOIMRFZSA-N
SMILES: O[C@@]12[C@@H]([C@@H](C[C@@](C([C@H](/C=C/C(C)([C@@]3([H])O[C@@]([C@@H]2O)(CC3)C)C)C)=O)([H])O1)C)OC(/C=C(C)/CC)=O
Biological Activity: Tonantzitlolone is a diterpenoid natural product found in Stillingia lineata ssp. lineata, and is a selective and reversible agonist of human TRPC1/4/5 ion channels. Tonantzitlolone reduces cancer cell viability and shows selectivity markedly restricted to a single cancer cell line. Tonantzitlolone can be used in research related to Merkel cell carcinoma and renal cell carcinoma[1][2][3].
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Tonantzitlolone | Tonantzitlolone is a diterpenoid natural product found in Stillingia lineata ssp. lineata, and is a selective and reversible agonist of human TRPC1/4/5 ion channels. Tonantzitlolone reduces cancer cell viability and shows selectivity markedly restricted to a single cancer cell line. Tonantzitlolone can be used in research related to Merkel cell carcinoma and renal cell carcinoma. | |||||||||||||||||||||
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References
- [1]. Smith EA, et al. Identification of natural product modulators of Merkel cell carcinoma cell growth and survival. Scientific reports. 2021 Jun 30;11(1):13597.
- [2]. Fash DM, et al. Synthesis of a stable and orally bioavailable englerin analogue. Bioorganic & medicinal chemistry letters. 2016 Jun 01;26(11):2641-4. [Content Brief]
- [3]. Rubaiy HN, et al. Tonantzitlolone is a nanomolar potency activator of transient receptor potential canonical 1/4/5 channels. Br J Pharmacol. 2018 Aug;175(16):3361-3368.
