848133-17-5
848133-17-5
Chemical Structure
HKI-357
- CAS No.: 848133-17-5
- Formula:C31H29ClFN5O3
- Molecular Weight:574.05
IUPAC Name: (E)-N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide
InChIKey: NERXPXBELDBEPZ-RMKNXTFCSA-N
SMILES: O=C(NC1=C(OCC)C=C2N=CC(C#N)=C(NC3=CC=C(OCC4=CC=CC(F)=C4)C(Cl)=C3)C2=C1)/C=C/CN(C)C
Biological Activity: HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2 with IC50s of 34 nM and 33 nM, respectively. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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HKI-357 | 98.10% | HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2 with IC50s of 34 nM and 33 nM, respectively. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation. | ||||||||||||||||||||
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HKI-357 (Standard) | ≥98% | HKI-357 (Standard) is the analytical standard of HKI-357 (HY-103443). This product is intended for research and analytical applications. HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2 with IC50s of 34 nM and 33 nM, respectively. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.85
HY-32721RNeratinib (Standard) -
Similarity Score 0.84
HY-103443AHKI-357 dimaleate -
Similarity Score 0.78
HY-32721BNeratinib maleate -
Similarity Score 0.77
HY-32718Pelitinib -
Similarity Score 0.76
HY-32721SNeratinib-d6 -
Similarity Score 0.74
HY-147303Sacibertinib -
Similarity Score 0.73
HY-104065Pyrotinib -
Similarity Score 0.73
HY-104065AR(Rac)-Pyrotinib (Standard) -
Similarity Score 0.72
HY-Z4775Neratinib impurity13 -
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