851176-40-4
851176-40-4
Chemical Structure
PP185
- CAS No.: 851176-40-4
- Formula:C11H14ClNO2
- Molecular Weight:227.69
IUPAC Name: 2-chloro-N-(3-methoxybenzyl)-N-methylacetamide
InChIKey: FLRJYXOMRJLWLV-UHFFFAOYSA-N
SMILES: O=C(N(C)CC=1C=CC=C(OC)C1)CCl
Biological Activity: PP185 is a insulin receptor kinase substrate. PP185 undergoes rapid tyrosine phosphorylation, with activity dependent on divalent cations and inhibited by insulin receptor kinase domain antibodies. PP185 can be used for the research of neuroblastoma[1][2][3].
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PP185 | PP185 is a insulin receptor kinase substrate. PP185 undergoes rapid tyrosine phosphorylation, with activity dependent on divalent cations and inhibited by insulin receptor kinase domain antibodies. PP185 can be used for the research of neuroblastoma. | |||||||||||||||||||||
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References
- [1]. Biggs GS,et al. Robust proteome profiling of cysteine-reactive fragments using label-free chemoproteomics. Nat Commun. 2025 Jan 2;16(1):73. [Content Brief]
- [2]. Shemer J, et al. Insulin and insulin-like growth factor-I stimulate a common endogenous phosphoprotein substrate (pp185) in intact neuroblastoma cells. J Biol Chem. 1987;262(32):15476-15482. [Content Brief]
- [3]. Tashiro-Hashimoto Y, et al. Tyrosine phosphorylation of pp185 by insulin receptor kinase in a cell-free system. J Biol Chem. 1989;264(12):6879-6885. [Content Brief]
Keywords
